Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotores: J. Zaanen, A. Parnachev

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Het onderzoek van de sectie Cognitieve Psychologie is onder te verdelen in twee domeinen.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Lezing

Promotie

Promotie

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?

Promotie

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotores: G.A. Persoon, H.H. de Iongh

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

In-use stocks of products can be considered as intermediaries between human needs and the physical world.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Het onderzoek van de sectie Gezondheids-, Medische en Neuropsychologie richt zich op de psychologische aspecten van gezondheid en ziekte, en op het ontwikkelen van innovatieve behandelingen.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotie

Leeuwen beperken hun prooidieren, zoals zebra’s en gnoes, in hun mogelijkheden zich aan te passen aan een opwarmende aarde. Dat ontdekte Leidse onderzoeker Michiel Veldhuis van het Centrum voor Milieuwetenschappen in Leiden samen met internationale collega’s. Het onderzoek is op 1 juni in Nature Ecology…

Lezing, Seminar

Promotie

Wiskunde en Natuurwetenschappen, Hortus botanicus Leiden

Op donderdag 26 januari 2017 verdedigt Anouk Bosma haar proefschrift ‘Targeting recidivism: An evaluation study into the functioning and effectiveness of a prison-based treatment program’. Promotor is prof. dr. Paul Nieuwbeerta, en copromotor dr. mr. Maarten Kunst.

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

In this project of the Center for Public Values & Ethics (CPVE) ongoing research is conducted on the history of advice to Dutch central government by so-called State committees from 1814 to 2014. State committees have been installed by Dutch central government since 1814 to provide expert advice, research…

Hoe kunnen we kwaliteit van leven en studiesucces vergroten bij jonge, hoog-functionerende volwassenen met autisme?

The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Geesteswetenschappen, Nederlands Instituut Marokko

Rechtsgeleerdheid

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.

What is the effect of light at night on plant phenology and physiology, and how does this affect plant interactions with other species?

How does the management of Elephant Marsh Fishery in Malawi relate to wider contexts of policies, theories and regions? And how can the current management system be adapted to achieve long-term sustainability of the fishery?

Voor allerlei zaken zijn wij afhankelijk van de natuur: van schoon water, hout en voedsel tot koolstofopname, waterzuivering en kustbescherming. Maar ook ontspanning, inspiratie en identiteit. In onze moderne wereld staan deze zogeheten ‘ecosysteemdiensten’ steeds meer onder druk. Leidse wetenschappers…