Governance and Global Affairs

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Promotor: G.J. Kramer Co-Promotor: E.G.M. Kleijn

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?

Which traits and/or trade-offs determine benefits of being deciduous or evergreen?

Het onderzoeksproject van Prof.Dr. Arjen Doelman ‘Adaptive Semi-Strong Ecosystem Dynamics’ is geselecteerd voor financiering als een van de 7 onderzoeksprojecten binnen het programma Mathematics of Planet Earth (MPE) van NWO.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Het EU-UNAWE project van de Universiteit Leiden inspireert kansarme jonge kinderen met het heelal en presenteert met trots deze lichte, opgeblazen versie van onze planeet. De Earth Ball is een eenvoudig hulpmiddel voor in de klas en wordt geleverd met een activiteitenboek vol ideeën over hoe dit lesmateriaal…

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Developing methodes to understand the evolution of patches in natural ecosystems

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: S.M. Verduyn Lunel

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Promotores: W. Jiskoot, F. Ossendorp

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: Prof.dr. M. Ubbink