Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Unfolding potential

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

Promotor: Prof.dr. S.F. Portegies Zwart

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotor: W.Th.F. den Hollander

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: Prof.dr. G.J. Kroes

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: Prof.dr. H.A.G. Wijshoff

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

With tomography it is possible to reconstruct the interior of an object without destroying.

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov

An assessment approach that tailors to children’s instructional needs

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Promotor: Prof.dr.ir. E. Deprettere

Onderzoekers van het Leiden Institute of Advanced Computer Science (LIACS) ontwikkelen een systeem dat automatisch waarschuwingen uitstuurt wanneer onderdelen van motoren de eerste verschijnselen van vermoeidheid beginnen te vertonen. Het project duurt 4 jaar.

Promotor: J.W. van Holten

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Developing methodes to understand the evolution of patches in natural ecosystems

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Promotie

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

De Duitse hoogleraar Information Systems and Statistics Heike Trautmann aanvaardde deze maand de Pascalleerstoel bij LIACS, het informatica-instituut aan de Universiteit Leiden. Trautmanns belangrijkste vakgebieden zijn evolutionary multiobjective optimisation en data science, waar ook LIACS sterk in…

Het onderzoek in dit proefschrift kijkt naar de rol van het locus ceuruleus - noradrenalinesysteem in verscheidene aspecten van menselijke cognitie, en de modulatie van de staat van het brein.