787 zoekresultaten voor “dose-response modelling” in de Publieke website
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Modelling the lung in vitro
Promotie
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Statistiek als je modellen niet kloppen
Peter Grunwald
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Synthetic model microswimmers near walls
Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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Optimally weighted ensembles of surrogate models for sequential parameter optimization
It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Enriching official economic statistics using data-driven modelling techniques
Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.
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spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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PhD candidate, Computational modelling for drug safety prediction
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Impact assessment modelling of matter-less stressors in the context of Life Cycle Assessment
Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs
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Het gebruik van een praktisch didactisch model door beginnend docenten voor het leren ontwerpen van lessen
Beginnend docenten hebben vaak moeite met het maken van activerende lessen. In dit onderzoek wordt gekeken hoe het didactisch bouwstenen model hen een helpende hand kan bieden bij het leren ontwerpen van lessen.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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A monodromy criterion for existence of Neron models and a result on semi-factoriality
In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.
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Gerard van Westen: 'Ons model voorspelt wat kandidaat-medicijnen doen in je lijf'
Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…
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Understanding membrane fusion at the molecular level using a biomimetic model system
Kros
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Accurate Modeling of the Dynamics of Dissociative Chemisorption on Metal Surfaces
Promotie
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.
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Zenuwsignalen doen de wave: nieuw wiskundig model
Elektrische signalen bewegen als een golf door onze zenuwbanen. De wiskundige modellen voor deze bewegingen konden nog niet alle biologische eigenschappen van de zenuwbanen goed beschrijven. Promovendus Willem Schouten-Straatman bracht hier verandering in door de bestaande modellen te verbeteren. 'Ik…
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José MogollónWiskunde en Natuurwetenschappen
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Medicijnafbraak bij kinderen: wat gebeurt er in de nieren?
Welke dosis geneesmiddel geef je een kind? Dat hang voor een groot deel van af van hoe snel hun nieren dit medicijn weer uit het bloed verwijderen. Om ethische redenen is het onmogelijk om dit bij jonge patiënten te meten. Promovenda Sinziana Cristea combineerde verschillende modelleermethodes en veel…
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Minder fouten in software features door delta modelling
Bij het programmeren van nieuwe features in software worden makkelijk veel fouten gemaakt. Hierdoor ontstaan bugs, die ertoe leiden dat software later op de markt komt en duurder is. Michiel Helvensteijn, promovendus van CWI en het Leiden Institute of Advanced Computer Science, onderzocht manieren om…
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Interactieve modellen: NWO TOP-subsidie voor Matthijs van Leeuwen
Matthijs van Leeuwen van het Leiden Institute of Advanced Computer Science ontwikkelt methodes om interactief naar de juiste computermodellen te zoeken. Hierbij kunnen experts informatie uit ruwe data combineren met hun eigen kennis om zo voorspellingen accurater te maken. ‘Op deze manier hopen we modellen…
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Aan de wieg van farmacologische modellen
Na 41 jaar neemt Meindert Danhof, hoogleraar Farmacologie, op 31 maart afscheid van het Leiden Academic Centre for Drug Research. Een symposium ter ere van hem, voorafgaand aan het afscheidscollege, laat zien wat er in die periode bereikt is. Danhof kijkt met plezier terug.
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Martha DellarWiskunde en Natuurwetenschappen
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using population pharmacokinetic and physiology based pharmacokinetic modeling approaches
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Beth LloydFaculteit der Sociale Wetenschappen
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New Business models for the Legal Services Market
Linking Empirical Academic thinking with Legal Practice. Internationally and particularly in the Netherlands. By René Orij, April, 2016.
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Xining YangWiskunde en Natuurwetenschappen
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Suiting DingWiskunde en Natuurwetenschappen
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Georgios PallasWiskunde en Natuurwetenschappen