Promotor: M.K. Richardson, Co-Promotor: F. Witte

The path to rational drug and dose selection

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

Promotor: P.D. Grünwald

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

Waarschuwingskleuren zorgen ervoor dat roofdieren onthouden dat bepaalde prooien giftig zijn. Maar nu blijkt dat de kleuren van Panamese gifkikkers ook door kieskeurige vrouwtjes worden beïnvloed: partnerkeuze kan ook bij deze dieren tot kleurverandering leiden, schrijft Leids promovendus Martine Maan…

Promotie

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Promotor: A.W. van der Vaart

During the course of drug discovery translational steps are made.

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…

Promotie

Promotie

Promotor: Prof.dr. T.H.W. Bäck

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Indicators to measure progress in de-linking economic growth and environmental pressure.

Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

The theme of the Research School for Medieval Studies' Medieval Studies' Day 2022 (UvA, Amsterdam, 4 November 2022) is Reflections. Please find the registration links below the programme. Questions? Please contact medievistendag2022@gmail.com.

Leiden Learning & Innovation Centre

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Rechtsgeleerdheid

Promotor: P.M. Brakefield

ICLON, Leiden Learning & Innovation Centre

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Governance and Global Affairs

The KNIR organises up to three Colloquia each year with no more than fifteen participants. All university lecturers working at an NWIB University can apply for this. The selection of candidates focuses on the quality of the application, on motivation and on the relationship with KNIR, Rome and/or Italy.…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent

Promovendus Niek Strohmaier heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Cognition & Emotion, met de titel: “Bypassing the gatekeeper: incidental negative cues stimulate choices with negative outcomes”. Dit artikel onderzoekt in brede zin welke factoren van invloed zijn op de keuzes…

The Keuzegids Universiteiten 2015 (Guide for Study Choice Universities) has awarded Leiden University with five ‘Top Rated Programmes’: Mathematics, Biomedical Sciences, Greek and Latin Language and Culture, Liberal Arts & Sciences: Global Challenges and Philosophy.

Stéphanie van der Pas heeft bij de Leidse Universitaire Scriptieprijzen 2014 de eerste plaats behaald met haar scriptie “Almost the Best of Three Worlds: The Switch Model Selection Criterion for Single Parameter Exponential Families.”

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

Wiskunde en Natuurwetenschappen, Lorentz Center

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)