Promotores: J. Zaanen, A. Parnachev

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

How can we quantify the density of species within a community through environmental DNA concentrations?

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Dissociative chemisorption is an important reaction step in many catalytic reactions.

Promotor: G. J. Kroes

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

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Promotor: Prof.dr. G.J. Kroes

The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.

Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

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The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: Prof.dr. P. Stevenhagen

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.