1,687 zoekresultaten voor “delta modeling” in de Publieke website
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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Minder fouten in software features door delta modelling
Bij het programmeren van nieuwe features in software worden makkelijk veel fouten gemaakt. Hierdoor ontstaan bugs, die ertoe leiden dat software later op de markt komt en duurder is. Michiel Helvensteijn, promovendus van CWI en het Leiden Institute of Advanced Computer Science, onderzocht manieren om…
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Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
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Delta-Institute for Theoretical Physics
Waar gaan de quantummechanica, de relativiteitstheorie en de zwaartekracht elkaar vinden? Wat is het missende stukje? Of is er een compleet nieuwe theorie die alle vormen van materie elegant beschrijft?
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Computational modeling of angiogenesis : from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
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Minimal structure modeling
Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…
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Self-regulation models
... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Zeven nieuwe Medical Delta-hoogleraren
Medical Delta benoemt zeven hoogleraren die een brug gaan slaan tussen de medische werelden van Leiden, Delft en Rotterdam.
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‘Medical Delta’: eenmalig magazine over de medische zorg van morgen
Binnen Medical Delta bundelen de TU Delft, Leids Universitair Medisch Centrum, Erasmus MC, de Universiteit Leiden en de Erasmus Universiteit Rotterdam reeds enkele jaren hun krachten om te werken aan oplossingen voor gezondheidsvraagstukken van vandaag en morgen.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.
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Development of a Dynamic Substance Stock Model
Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Statistiek als je modellen niet kloppen
Peter Grunwald
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Quantitative modelling of the response of earthworms to metals
Promotor: Prof.dr. W.J.G.M. Peijnenburg
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Nederlandse Medical Delta kan zich meten met Europese medische topregio’s
Een nieuwe analysemethode waarmee Europese medisch-technologische ‘Silicon Valleys’ hun economische status quo kunnen meten, laat zien dat de Nederlandse Medical Delta goed scoort op onder meer kennisbasis, industriële samenwerking en aantal spin-off-bedrijven. De analysetool en de eerste resultaten…
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Joop van Holsteyn & Josje den Ridder (red.), Van driestromenland tot delta? Beschouwingen over ontwikkelingen in de Nederlandse politiek
Lange tijd werd de Nederlandse politiek gedomineerd door drie ideologische stromingen: de christendemocratie, de sociaaldemocratie en het liberalisme. Inmiddels zijn deze hoofdstromen smaller geworden en zijn er ter linker- en rechterzijde diverse nieuwe politieke stromen en stroompjes ontstaan. In…
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Optimally weighted ensembles of surrogate models for sequential parameter optimization
It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.
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quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Modeling interstellar bubbles: near and far
Promotor: Prof. dr. A.G.G.M. Tielens
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in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Better Predictions when Models are Wrong or Underspecified
Promotor: P.D. Grünwald
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The parabolic Anderson model and long-range percolation
Promotor: Prof.dr. F. den Hollander, G.Maillard
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Constraint-Based Analysis of Business Process Models
Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Dubbelbenoeming zeven nieuwe Medical Delta-hoogleraren
Zeven nieuwe Medical Delta-hoogleraren ontvouwen hun onderzoeksplannen in een oratiemarathon op 21 juni. De hoogleraren van de Universiteit Leiden, het LUMC, de TU Delft en het Erasmus MC Rotterdam opereren op het snijvlak van de life sciences en gezondheid en technologie.
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A recipe for desert: analysis of an extended Klausmeier model
Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk
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Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Enriching official economic statistics using data-driven modelling techniques
Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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PHD candidate, Mathematical modeling for prediction of liver toxicity
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Lattice models for Josephson junctions and graphene superlattices
In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Medical Delta AI for Computational Life Sciences
Nu het steeds beter lukt om de moleculaire gegevens van cellen en weefsels te ontsluiten, schept dat ook direct een nieuwe uitdaging. Want hoe vind je uit die enorme hoeveelheid data de juiste informatie voor onderzoek?
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
Promotie