Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Bij het programmeren van nieuwe features in software worden makkelijk veel fouten gemaakt. Hierdoor ontstaan bugs, die ertoe leiden dat software later op de markt komt en duurder is. Michiel Helvensteijn, promovendus van CWI en het Leiden Institute of Advanced Computer Science, onderzocht manieren om…

Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…

Waar gaan de quantummechanica, de relativiteitstheorie en de zwaartekracht elkaar vinden? Wat is het missende stukje? Of is er een compleet nieuwe theorie die alle vormen van materie elegant beschrijft?

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Promotor: Roeland M.H. Merks

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

... which builds on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Medical Delta benoemt zeven hoogleraren die een brug gaan slaan tussen de medische werelden van Leiden, Delft en Rotterdam.

Binnen Medical Delta bundelen de TU Delft, Leids Universitair Medisch Centrum, Erasmus MC, de Universiteit Leiden en de Erasmus Universiteit Rotterdam reeds enkele jaren hun krachten om te werken aan oplossingen voor gezondheidsvraagstukken van vandaag en morgen.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Peter Grunwald

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: B.van de Water, Co-promotor: L.S.Price

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

Een nieuwe analysemethode waarmee Europese medisch-technologische ‘Silicon Valleys’ hun economische status quo kunnen meten, laat zien dat de Nederlandse Medical Delta goed scoort op onder meer kennisbasis, industriële samenwerking en aantal spin-off-bedrijven. De analysetool en de eerste resultaten…

Lange tijd werd de Nederlandse politiek gedomineerd door drie ideologische stromingen: de christendemocratie, de sociaaldemocratie en het liberalisme. Inmiddels zijn deze hoofdstromen smaller geworden en zijn er ter linker- en rechterzijde diverse nieuwe politieke stromen en stroompjes ontstaan. In…

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: Prof. dr. A.G.G.M. Tielens

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotor: P.D. Grünwald

Promotor: Prof.dr. F. den Hollander, G.Maillard

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Promotor: Prof.dr. J.N. Kok

Zeven nieuwe Medical Delta-hoogleraren ontvouwen hun onderzoeksplannen in een oratiemarathon op 21 juni. De hoogleraren van de Universiteit Leiden, het LUMC, de TU Delft en het Erasmus MC Rotterdam opereren op het snijvlak van de life sciences en gezondheid en technologie.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Nu het steeds beter lukt om de moleculaire gegevens van cellen en weefsels te ontsluiten, schept dat ook direct een nieuwe uitdaging. Want hoe vind je uit die enorme hoeveelheid data de juiste informatie voor onderzoek?

Promotor: Prof.dr. B.R. Katzy

Promotie