In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…

Promotores: S.J. Edixhoven, F. Andreatta

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Marokko is een van de weinige landen in Noord-Afrika die aan de Arabische lente een vreedzame vorm heeft weten te geven door het pad van brede, gestage politieke hervormingen op te gaan. De Marokkaanse overheid verklaart de relatieve maatschappelijke rust daarnaast ook door haar islampolitiek, gericht…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Computationeel bioloog dr. Joost Beltman wordt vanaf oktober 2014 aangesteld als assistant professor bij het Leiden Academic Centre for Drug Research (LACDR) van de Universiteit Leiden. Beltman neemt een NWO Vidi-subsidie mee vanuit het Nederlands Kanker Instituut (NKI) die hij in 2013 kreeg om computationeel…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Richard D. Gill

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotores: J. Jonkers, K.E. de Visser

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

Including modelling as part of software development appears to have various benefits.

Een nieuwe infrastructuur voor onderzoeksdata in computationele sociale wetenschappen

Promotor: S.M. Verduyn Lunel

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotor: P.D. Grünwald

This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Lezing, Studium Generale

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Oratie

Het ontwikkelen, gebruiken en evalueren van groepsopdrachten in het hoger onderwijs.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

The ReCiPe methodology for Life Cycle Impact Assessment (LCIA).

Promotor: F.P. Israel, Co-Promoter: R. Meijerink

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

Promotie

This thesis discusses the discovery potential of Intensity Frontier experiments.

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)