1,640 zoekresultaten voor “computational modeling” in de Publieke website
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Rachel Schats
Rachel Schats is Assistant Professor in Human Osteoarchaeology in the Faculty of Archaeology, Leiden University.
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LCN2 Seminar
Lezing
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Theorie
Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…
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Theorie
Veel belangrijke onderwerpen in de informatica, zoals de juistheid van software, de efficiëntie van algoritmen en de modellering van gecompliceerde systemen, zijn afhankelijk van een goede theoretische onderbouwing. In de Theoriegroep bestuderen we deze fundamentele bouwstenen en ontwikkelen we verificatiemethoden…
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ARC session: Models of Music Creation and Improvisation
Kunst en Cultuur
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Consortium DDMoRE lanceert open-access databank
Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.
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Student sterrenkunde krijgt een 10 voor onderzoek naar chaotische zwarte gaten
De Leidse masterstudent Arend Moerman heeft een tien gekregen voor zijn afstudeeronderzoek naar de simulatie van de chaotische interacties van drie zwarte gaten. Uit de simulaties blijkt dat lichtere zwarte gaten elkaar meestal wegslingeren, terwijl zwaardere vooral samensmelten. Het onderzoek, een…
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Modelling the role of cytotoxic T lymphocytes in tumour regression
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
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Cellular models for fundamental and applied biomedical research
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Biomimetic Models of [NiFe] Hydrogenase for Electrocatalytic Hydrogen Evolution
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Constraint-Based Analysis of Business Process Models
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Global Scenarios of Environmental Impacts with Structural Economic Models
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Precision modeling of breast cancer in the CRISPR era
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Bergson and the Aristotelian model of immanent teleology
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EuDEco Report on the legal analysis (D2.2)
D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…
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Topics in mathematical and applied statistics
Promotor: A.W. van der Vaart
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Methodologie en Statistiek
Methodologie & Statistiek richt zich op de ontwikkeling, evaluatie en toepassing van modellen voor de analyse van psychologische onderzoeksgegevens.
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Elke Krekels bij Science071: Hoe bepaal je de juiste medicijndosering voor kinderen?
Hoe bepaal je bij een kind de juiste dosering van een medicijn? Dat kan niet altijd op basis van lichaamsgewicht. Maar soms kan dat wèl, ontdekte farmacoloog Elke Krekels. Ze won hiermee de TOP-Publicatieprijs van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie. In de uitzending…
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Solving multiplication and division problems
Latent variable modeling of students' solution strategies and performance
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)
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Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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The individual level effect of symbolic representation: An experimental study on teacher-student gender congruence and students’ perceived abilities
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
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Revealing the nature of new low-frequency radio source populations
It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
- LCN2 Seminar: Systemic instability in networks
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This Week's Discoveries | 7 May 2019
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Taking Place: Parrhesiastic Theater as a model for artistic practice
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Onderzoek
Aan de Universiteit Leiden werken wetenschappers uit alle disciplines samen om antwoorden te vinden en om te innoveren op het gebied van kunstmatige intelligentie.
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ANO-NET: Anonimiteit in complexe netwerken
Dit project ontwikkelt methoden om de anonimiteit van individuen in sociale netwerkgegevens te waarborgen.
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Marcus Specht sluit aan bij PERL als Hoogleraar Digital Education
Marcus Specht, directeur van het LDE Center of Education and Learning, is sinds 15 november aangesteld als Hoogleraar Digital Education. Hij heeft gezamelijke benoemingen bij de drie LDE universiteten. In Leiden zal hij zich aansluiten bij Felienne Hermans in het Programming Education Research Lab (…
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Junior Researcher
Afrika-Studiecentrum Leiden
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Full Professor in Artificial Intelligence in Medicinal Chemistry
Wiskunde en Natuurwetenschappen
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Full Professor in Humanities and AI
Geesteswetenschappen