Promotor: Roeland M.H. Merks

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Promotie

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Promotor: Prof.dr. H.V.J. Linnartz

Promotie

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Peter Grunwald

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Promotor: Prof. dr. A.G.G.M. Tielens

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

Het Leiden Institute of Advanced Computer Science feliciteert alumnus Pepijn van Heiningen en de met de Technische Hochschule Köln gedeelde promovenda Samineh Bagheri. Allebei wonnen ze afgelopen week op het SSCI 2016 congres over computational intelligence in Athene een award voor de hoge kwaliteit…

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Beginnend docenten hebben vaak moeite met het maken van activerende lessen. In dit onderzoek wordt gekeken hoe het didactisch bouwstenen model hen een helpende hand kan bieden bij het leren ontwerpen van lessen.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotor: Prof.dr. M.K. Richardson

Promotores: H. Schiessel, G.T. Barkema

Prostate cancer (PCa) is one of the most prevalent cancer in males.

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Kros

Promotie

Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.

Elektrische signalen bewegen als een golf door onze zenuwbanen. De wiskundige modellen voor deze bewegingen konden nog niet alle biologische eigenschappen van de zenuwbanen goed beschrijven. Promovendus Willem Schouten-Straatman bracht hier verandering in door de bestaande modellen te verbeteren. 'Ik…

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Oratie