Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Unfolding potential

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Valetudo, zo hebben de astronomen het nieuw ontdekte Jupitermaantje genoemd. Het is een weerbarstig exemplaar dat dwars tegen haar soortgenoten in beweegt. In de Volkskrant reageert Leidse astronoom Simon Portegies Zwart op de bijzondere ontdekking.

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: Roeland M.H. Merks

Veel kinderen leren niet op een niveau dat aansluit bij hun potentieel om te leren. Diagnostiek in de leerlingbeleiding zou daarom inzicht moeten geven in hoe een kind begeleid kan worden in het verder ontwikkelen van zijn of haar sterke kanten terwijl het tegelijkertijd handvatten biedt voor het ondersteunen…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.

The ERC project ‘Healthscaping Urban Europe’ will hold a concluding plenary event on 30 September, where three experts will explore the history of premodern public health and especially reflect on possible future directions within this research field. All are welcome to join in person in the Doelenzaal.…

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: W.Th.F. den Hollander

Sociale Wetenschappen

Promotor: J.W. van Holten

An assessment approach that tailors to children’s instructional needs

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Promotor: Prof.dr. J.N. Kok

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Developing methodes to understand the evolution of patches in natural ecosystems

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

Promotor: Prof.dr. G.J. Kroes

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)