329 zoekresultaten voor “chronic disease” in de Publieke website
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.
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Modeling Vascular Diseases Using Human Induced Pluripotent Stem Cells
Promotie
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Huisartsgeneeskunde: Leerstoel e-health toepassingen in disease management
Oratie
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Detecting hidden variation in our genome
Novel algorithms to detect indels and structural variants from next- and third-generation sequencing data.
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Novel insights into blood markers and cardiovascular disease
Promotie
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Nieuwe stoffen remmen ontsteking in het brein
Leidse chemisch biologen, onder leiding van dr. Mario van der Stelt, hebben stoffen ontdekt die ontstekingsprocessen in de hersenen kunnen verminderen. Daarmee is een eerste stap gezet in de ontwikkeling van potentiële geneesmiddelen voor de behandeling van hersenziekten zoals de ziekten van Alzheimer…
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Mesenchymal stromal cell therapy for Crohn’s disease
Promotie
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BMP signaling in vascular and heterotopic bone diseases
Promotie
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Lipids as therapeutic targets for barrier repair in skin diseases
Promotie
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Cardiometabolic disease in South Asians: risk factors and therapeutic strategies
Promotie
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ecurrent miscarriage and the subsequent risk of cardiovascular disease
Promotie
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Chromatin modifiers in DNA repair and human disease
Promotie
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Glycoproteomic characterization of immunoglobulins in health and disease
Promotie
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Impact of Huntington's disease on working and driving
Promotie
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Endothelial WT1 and the epicardium in cardiac development and disease
Promotie
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Enhanced monitoring and screening in pediatric coeliac disease
Promotie
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Functional and structural neuroimaging in Huntington's disease
Promotie
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Combatting metabolic disease. Ethnic aspects, mechanisms and novel treatment strategies
Promotie
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Efficacy, safety and novel targets in cardiovascular disease
Promotie
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spatial transcriptomics and neuroimaging data in neurodegenerative diseases
Promotie
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Aortic Valve Disease: Novel Imaging Insights from Diagnosis to Therapy
Promotie
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Value-Based Health Care in Inflammatory Bowel Diseases
Promotie
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Neuropsychiatric symptoms and immune system parameters in Huntington's Disease
Promotie
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Promotie
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Artificial Intelligence and eHealth for Inflammatory Bowel Diseases
Promotie
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Genetics and epigenetics of repeat derepression in human disease
Promotie
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Ocular inflammation in age-related eye diseases
Promotie
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Multimodality imaging in ischemic heart disease, from prevention to outcome
Promotie
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Optical coherence Tomography for Coronary Artery Disease: Analysis and Applications
Promotie
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Consortium DDMoRE lanceert open-access databank
Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.
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Celtypes in kaart gebracht van foetale nier
Nierfalen is een serieus probleem omdat nieren zichzelf niet kunnen regenereren na ernstige beschadiging. Een mogelijke oplossing bestaat uit het kunstmatig laten groeien van gezond nierweefsel. Daarvoor moeten wetenschappers eerst de ontwikkeling begrijpen tijdens de allereerste fase, in de foetus.…
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Menière's disease: clinical aspects, diagnostic tests and interventions
Promotie
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UITGESTELD |Menière's disease: clinical aspects, diagnostic tests and interventions
Promotie
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Natural and non-natural factors influencing Alzheimer´s Aβ
Promotor: Prof.dr. J.P. Abrahams
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Levensverlengend gen bij planten ontdekt
Oogst na oogst binnenhalen van rijstveld, zonder nieuwe rijstplanten te zetten? Door een ontdekking komt dit scenario misschien wel dichterbij. Leidse wetenschappers hebben een gen ontdekt waarmee ze eenjarige planten na het bloeien opnieuw laten groeien, in plaats van dat de planten sterven. Publicatie…