329 zoekresultaten voor “chronic disease” in de Publieke website
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Gezondheidspsychologen Yvette Meuleman en Kaya Peerdeman ontvangen ARPH Awards
Tijdens de jaarlijkse bijeenkomst van de Association for Researchers in Psychology and Health (ARPH) op 15 januari 2019 heeft Kaya Peerdeman de ARPH Young Talent Award gewonnen. De ARPH Best PhD Thesis Award gaat naar Yvette Meuleman.
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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TechTalk: Infectious Diseases
Lezing
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Clinical predictors of disease progression in Parkinson's disease
Promotie
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Pain perception and modulation in acute and chronic pain states
Promotie
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Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
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Obesity and Cardiovascular Disease
Promotie
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Suicidality in Huntington's disease
Promotie
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Omics profiling of cardiometabolic diseases
Promotie
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Huntington Disease and other Polyglutamine Diseases: Using CAG repeat variations to explain missing heritability
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
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Functional and metabolic characterization of endothelial cells in chronic thromboembolic pulmonary hypertension
Promotie
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Stromal cells in Inflammatory Bowel Disease
Promotie
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Hemolytic disease of the fetus and newborn
Promotie
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Mesenchymal Stromal Cell in Pediatric Disease
Promotie
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Complement Biology in Health and Disease
Promotie
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Bicuspid aortic valve disease: Morpholoy matters
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Future drugs in atherosclerotic cardiovascular disease
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Coeliac Disease: Prevention and Improvement of Care
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Zebrafish as vertebrate model of Gaucher disease
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Blood and biomarkers in Huntington’s Disease
Promotie
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Multimodality Imaging for Valvular Heart Disease Characterisation
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New neuroimaging approaches in Parkinson's disease
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Surgical therapy of organic mitral valve disease
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The Huntingtin protein in Huntington disease
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Huntington's disease Cognition and Apathy
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Phenotyping cardiometabolic disease with magnetic resonance techniques
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Knowledge discovery methods for Huntington’s Disease
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Right ventricular function assessment in cardiopulmonary disease
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Coach en kookboek helpen mensen met een chronische nierziekte
Hoge bloeddruk, overgewicht en diabetes hebben effect op de nierfunctie. Medisch psycholoog Yvette Meuleman van de Universiteit Leiden ging in gesprek met patiënten en zorgverleners, en ontwierp een leefstijlprogramma dat oog heeft voor de kwaliteit van leven. Promotie op 18 januari 2018.
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Music therapy in Huntington's disease
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Neuropsychiatric phenomena in Huntington's disease
Promotie