Overkleeft

Promotie

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Oratie

Thomas Bakkum en Tom van der Wel, promovendi bij het Leids Instituut voor Chemisch Onderzoek, winnen poster awards bij de EMBL Chemical Biology Conference 2018 in Heidelberg.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

NWO Chemische Wetenschappen heeft een TOP-PUNT subsidie toegekend aan een onderzoeksproject van chemicus prof.dr. Gijs van der Marel van de Universiteit Leiden en prof. dr. ir. A.J. Minnaard van de Rijksuniversiteit Groningen.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Lezing

Promotor: J. Schaye

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Lezing

Lezing

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Promotor: H.V.J. Linnartz

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Lezing

In deze opleiding kan je kiezen uit twee richtingen: Chemical Biology of Energy & Sustainability. Je krijgt de kennis en vaardigheden om een onafhankelijk en creatief wetenschapper te worden.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: Prof.dr. E.F. van Dishoeck

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

Lezing

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotie

Promotie

Promotie

Safety issues of the transport and storage of Chlorine, ammonia and LPG.

Curved single crystals provide variable, but well-defined surface structures.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

What are interactive effects of human pressures on aquatic communities?