437 zoekresultaten voor “cannabinoid receptor 1” in de Publieke website

• Chemical tools to study the cannabinoid receptor type 2 Onderzoeksoutput

  The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…

• Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors Onderzoeksoutput

  The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

• Synthetic carbohydrate ligands for immune receptors Onderzoeksoutput

  One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

• activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• The endocannabinoid system in zebrafish larvae Onderzoeksoutput

  In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

• Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus Onderzoeksoutput

  In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

• Drug-target residence time: a case for the adenosine A1 and A2A receptors Onderzoeksoutput

  Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

• mutations and identification of a selectivity hotspot in adenosine receptor Onderzoeksoutput

  G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

• to insurmountability: Novel avenues to better target CC Chemokine receptors Onderzoeksoutput

  This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

• Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors Onderzoeksoutput

  Promotor: A.P. IJzerman

• investigating kinetic interactions between drug, endogenous neuropeptides and receptor Onderzoeksoutput

  Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

• action : target binding kinetics and functional efficacy at the mGlu2 receptor Onderzoeksoutput

  During the course of drug discovery translational steps are made.

• Toll-like receptor signaling in the innate immune system of zebrafish larvae Onderzoeksoutput

  Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

• smarter: Artificial intelligence in drug design for G protein-coupled receptors Onderzoeksoutput

  Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

• The Function of Toll-like receptor 2 in Infection and Inflammation Onderzoeksoutput

  The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

• De moleculaire geheimen van medicinale cannabis Nieuws - 23 maart 2023

  Chronische pijn, misselijkheid of braken door chemotherapie. Als je er last van hebt, kan medicinale cannabis een uitkomst zijn. Het nadeel is alleen wel dat patiënten er high van kunnen worden. Leidse onderzoekers van het Oncode Instituut doen daarom onderzoek naar alternatieven waar je dat niet van…

• Chemical tools to study the cannabinoid receptor type 2 Agenda - 26 april 2018

  Promotie

• Pijnstilling zonder high te zijn Nieuws - 3 januari 2017

  Onderzoekers van de Universiteit Leiden onder leiding van Mario van der Stelt (Leids Instituut voor de Chemie) wijzen ‘gouden standaarden’ aan om nieuwe pijnstillers te ontwikkelen die gebaseerd zijn op de medicinale werking van cannabis. Publicatie in Nature Communications.

• Targeting of antigen-presenting cells with mannosylated conjugates Onderzoeksoutput

  This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

• Functie receptor voor goed HDL cholesterol in mens ontmaskerd Nieuws - 19 januari 2011

  HDL staat bekend als het ‘goede cholesterol’: het verlaagt de kans op hart- en vaatziekten. Sommige families hebben van nature veel HDL in het bloed. Onderzoek naar hun erfelijk materiaal kan bijdragen aan de ontwikkeling van nieuwe medicijnen die HDL verhogen.

• Self adjuvanting immunopeptides: Design and synthesis Onderzoeksoutput

  Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

• Russisch 1 Cursus
• Koreaans 1 Cursus
• Nederlands 1 Cursus
• Kroatisch 1 Cursus
• Frans 1 Cursus
• Chinees 1 Cursus
• Arabisch 1 Cursus
• Italiaans 1 Cursus
• Zweeds 1 Cursus
• Spaans 1 Cursus
• A chemical biology approach for targeting of ligand-drug conjugates Onderzoeksoutput

  Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

• Duits 1 Cursus
• Perzisch 1 Cursus
• Discovery of Reversible Monoacylglycerol Lipase Inhibitors Onderzoeksoutput

  Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

• Japans 1 Cursus
• Towards a mechanistic understanding of nanoparticle behavior using zebrafish Onderzoeksoutput

  The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

• Portugees 1 Cursus
• Key innate immune components controlling intracellular infection Onderzoeksoutput

  Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

• The ins and outs of ligand binding to CCR2 Onderzoeksoutput

  Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

• PMO in 1 dag Cursus

• Arabisch 1 + 2 Cursus
• Japans 1+2 Intensief Cursus
• Intensieve Wintercursus Nederlands 1 Cursus
• Basismodule Coachingsvaardigheden 1 Afdeling Nascholing

  De deelnemer leert tijdens deze module nieuwe of aankomende docenten te begeleiden bij hun professionele ontwikkeling. De deelnemer ontwikkelt algemene begeleidingsvaardigheden en neemt kennis van de nieuwste (vak)didactische ontwikkelingen.

• Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands Onderzoeksoutput

  Promotores: A.P. IJzerman, H.W.T. van Vlijmen

• Spaans 1+2 Intensief Cursus
• Frans 1+2 Intensief Cursus
• Kernvisie team 1 Kernvisie Bachelor onderwijs Juridische opleidingen

  Team 1 Vaardighedenlijn en interdisciplinariteit kernvisie