263 zoekresultaten voor “cancer metastasis” in de Publieke website
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The role of the Bone Morphogenetic Protein Pathway in Colorectal Cancer
Promotie
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Homologous Recombination Deficiency and BRCA1/2 Mutations in Endometrial Cancer
Promotie
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Interactions between the Tumor Microenvironment and Prostate and Oropharyngeal Cancer
Promotie
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
Promotie
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Coming of age: treatment and outcomes in older patients with breast cancer
Promotie
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The use of optical techniques to guide cancer diagnosis and radical surgical resections
Promotie
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Familial Melanoma and Pancreatic cancer: studies on genotype, phenotype and surveillance
Promotie
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Preoperative blood management in colorectal cancer surgery: the controversial role of iron
Promotie
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term fasting, IGF/insulin-axis and therapy outcome in patients with cancer
Promotie
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Ductal carcinoma in situ of the breast: cancer precursor or not?
Promotie
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Adjuvant treatment for endometrial cancer: Efficacy, toxicity and quality of life
Promotie
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
Promotie
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Patterns of care and prognosis of older women with breast cancer
Promotie
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Tailoring adjuvant therapy for hormone receptor-positive early breast cancer
Promotie
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Microenvironment Towards improving patient outcomes of immunotherapy in lung cancer
Promotie
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
Promotie
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
Promotie
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improve treatment strategies for patients with hepatic or pancreatic cancer
Promotie
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the molecular mechanism of transport decisions and Salmonella-induced cancer
Promotie
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Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
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genes driving tumorigenesis and therapy resistance in human breast cancer
Promotie
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High-dimensional profiling of immunotherapy responsive immune cells in cancer
Promotie
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Multi-parametric MRI to guide salvage treatment of recurrent prostate cancer
Promotie
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The microenvironment in colorectal cancer: an integrative histopathological, transcriptomic and metabolomic approach
Promotie
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Trouble - Exploring risk factors to better predict contralateral breast cancer
Promotie
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Immunosuppression in breast cancer: a closer look at regulatory T cells
Promotie
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The impact of one: single cell analysis of T cell states in human cancer
Promotie
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Ductal carcinoma in situ and invasive breast cancer: diagnostic accuracy and prognosis
Promotie
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and predictive application of the tumor-stroma ratio in colorectal cancer
Promotie
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The diverse roles of integrin α3β1 in cancer: lessons learned from skin and breast carcinogenesis
Promotie
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Untangling the immune landscape of colorectal cancer by in situ multiplex immunophenotyping
Promotie
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Partial Breast Irradiation in elderly patients with early-stage breast cancer
Promotie
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Cancer-induced somatic mutations in G protein-coupled receptors
Promotie
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Shared decision-making about treatments for early breast cancer: preferences of older patients and clinicians
Promotie
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Nieuwe hoogleraar gaat medicijnen ontwikkelen binnen academische wereld
Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.
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prognostic value of the tumor-stroma ratio in patients with breast cancer
Promotie
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The genetic etiology of familial breast cancer; Assessing the role of rare genetic variation using next generation sequencing
Promotie
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Somatic POLE exonuclease domain mutations in endometrial cancer – Insights into the biology of POLE-mutant tumors
Promotie
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Remote Control: the cancer cell-intrinsic mechanisms that dictate systemic inflammation and anti-tumor immunity
Promotie
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Studieprogramma
Bij Biomedische Wetenschappen word je opgeleid tot wetenschapper in het biomedisch veld. Wat houdt dat eigenlijk precies in en wat leer je allemaal in de bachelorfase?
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Broer en zus publiceren samen over hartproblemen bij zwangere vrouwen die kinderkanker hebben gehad
Broer en zus Julius (31) en Steffie (36) Heemelaar schreven als eerste en tweede auteur over hartproblemen bij zwangeren die op kinderleeftijd zijn behandeld voor kanker.
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…