229 zoekresultaten voor “breast cancer” in de Publieke website
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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Mechanisms regulating TGF-β and Wnt signal transduction in breast cancer
Promotie
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Quality assurance in breast cancer care and breast implant surgery
Promotie
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RNA splicing in breast cancer progression
Promotie
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The path to individualised breast cancer screening
Promotie
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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Tamoxifen pharmacogenetics and pharmacokinetics in early-breast cancer
Promotie
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Exploring Grainyhead-like 2 target genes in breast cancer
Promotie
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Hanging in there: Exploring the heritability of breast cancer survival
Promotie
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Immune cell complexity in the tumor microenvironment of breast cancer
Promotie
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Precision modeling of breast cancer in the CRISPR era
Promotie
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A comprehensive approach for quality assurance of breast cancer care
Promotie
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Tailoring adjuvant therapy for hormone receptor-positive early breast cancer
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Ductal carcinoma in situ of the breast: cancer precursor or not?
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of actomyosin contraction as a driving force of invasive lobular breast cancer
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Coming of age: treatment and outcomes in older patients with breast cancer
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uncover genes driving tumorigenesis and therapy resistance in human breast cancer
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Ductal carcinoma in situ and invasive breast cancer: diagnostic accuracy and prognosis
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Trouble - Exploring risk factors to better predict contralateral breast cancer
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Hereditary breast cancer and the clinical significance of variants in the BRCA1 and BRCA2 genes
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A Diffïcult Balancing Act: Informing breast cancer patients about adjuvant systemic therapy
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
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Optimizing breast cancer survival models based on conventional biomarkers and stromal parameters
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Integrating clinicopathological and molecular data in the breast cancer patient: Towards precision medicine
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Shared decision-making about treatments for early breast cancer: preferences of older patients and clinicians
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Immuunsysteem speelt dubbele rol bij borstkanker
Het immuunsysteem speelt een paradoxale rol bij de uitzaaiing van borstkanker. Dat ontdekte Kelly Kersten in haar promotieonderzoek. Sommige immuuncellen dragen bij aan uitzaaiingen, terwijl andere cellen kunnen worden aangezet om chemotherapie effectiever te maken. Promotie op 7 februari.
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the prognostic value of the tumor-stroma ratio in patients with breast cancer
Promotie
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Cancer Drug Discovery Initiative maakt nieuwe therapieën tegen kanker mogelijk
Het Antoni van Leeuwenhoek/Nederlands Kanker Instituut, het Leids Instituut voor de Chemie en het Pivot Park Screening Centre gaan kennis en infrastructuur delen in het Cancer Drug Discovery Initiative. Vrijdag 11 oktober tekenden ze een letter of intent.
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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The diverse roles of integrin α3β1 in cancer: lessons learned from skin and breast carcinogenesis
Promotie
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Haico van AttikumFaculteit Geneeskunde
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Erik Danen benoemd tot hoogleraar Cancer drug target discovery
Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.