28 zoekresultaten voor “biosynthesis” in de Publieke website
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Robert VerpoorteWiskunde en Natuurwetenschappen
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa
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Total Synthesis of Alginate and Zwitterionic Sp1 Oligosaccharides
The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Chemical Tools to Modulate Endocannabinoid Biosynthesis
Promotie
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Chemical Biology Lezing: Biosynthesis and Engineering of Cyclic Peptide Antibiotics
Lezing
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Activity-based protein profiling of diacylglycerol lipases
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Chemical synthesis of fragments of galactosaminogalactan and pel polysaccharides
The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.
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Endothelial Glycocalyx Hyaluronan Biosynthesis and Function in Microcirculation
Promotie
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
Promotie
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotie
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bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
Promotie
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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fungal endophytes in Vanilla planifolia on vanilla flavor compounds biosynthesis
Promotie
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Unilever Research Prize voor masterstudent Lukas Kiefer
Leidse Biologiestudent Lukas Kiefer heeft de Unilever Research Prize 2018 gewonnen voor zijn onderzoek naar de efficiënte productie van een nieuw antibioticum. Kiefer: 'Ik wil biologische medicijnen beschikbaar maken voor mensen in nood.'
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PhD position to study regulation and transport of a novel anti-diabetic plant derived metabolite
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Assistant/Associate Professor Biochemistry of the Bacterial Cell Wall and Cell Membrane (1.0 FTE)
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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This Week's Discoveries | 29 Mei 2018
Lezing