549 zoekresultaten voor “bioorthogonal chemistry” in de Publieke website
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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Sander van KasterenWiskunde en Natuurwetenschappen
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.
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Chemistry (MSc)
In deze opleiding, verzorgd door het Leiden Institute of Chemistry, zoek je naar oplossingen voor complexe, maatschappelijke problemen in volksgezondheid en milieuvraagstukken. We bieden op maat gemaakte, individuele studieprogramma’s, en je hebt de mogelijkheid om onderzoek te doen in het buitenland…
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Peptide amphiphiles and their use in supramolecular chemistry
Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Assistant/Associate/Full Professors in Chemistry (5 - 6 positions)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Assistant/Associate/Full Professors in Chemistry
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR), Leids Instituut voor Chemisch Onderzoek (LIC)
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Scrum in secondary chemistry education
In het schoolvak scheikunde is de concept-context benadering ingevoerd. Hans Vogelzang onderzocht of de Scrum-methodologie kan helpen bij het vormgeven van lessen met deze benadering.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Online Master's Experience Day Chemistry
Studievoorlichting
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PhD position in synthetic polymer chemistry
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Unlocking the chemistry of the heavens
Linnartz
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PhD Supramolecular Chemistry, Responsive Biomaterials for Therapeutics
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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PhD position in synthetic polymer chemistry
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Multiple star formation: chemistry, physics and coevality
Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.
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Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
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Postdoctoral researcher in the field of supramolecular chemistry
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Postdoctoral researcher in Supramolecular Chemistry and Chemical Biology
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Postdoc candidate in analytical chemistry / mass spectrometry / proteomics
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Full Professor in Artificial Intelligence in Medicinal Chemistry
Wiskunde en Natuurwetenschappen
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PhD in physical chemistry: operando spectroscopy on platinum electrocatalysts
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Postdoctoral researcher in Theoretical Chemistry (1.0 fte)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Breaking & Entering: PAH photodissociation and top-down chemistry
Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
Promotie
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Chemistry in embedded disks: setting the stage for planet formation
To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Oxidation catalysis on Pt and Au: complexity of simple chemistry
Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink
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Protoplanetary disk anatomy: examining the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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PhD candidate in bio-synthetic chemistry of small-molecule drugs targeting viral RNAs
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Non-equilibrium chemistry and cooling in simulations of galaxy formation
Promotor: J. Schaye
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PhD in physical chemistry: operando spectroscopy on IrOx and RuOx electrocatalysts
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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‘Chemistry in Conflict’ voor minister Bussemaker
Onderwijsminister Jet Bussemaker kreeg op de Dag van de Excellentie op 20 juni een exemplaar van ‘Chemistry in Conflict’, een educatief boek over de rol van chemie in oorlogsvoering. Ludo Juurlink, directeur van het Junior Science Lab, overhandigde het boek.
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Lies BouwmanWiskunde en Natuurwetenschappen
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Alexander KrosWiskunde en Natuurwetenschappen
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Transition metal compounds with S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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Superkleine scheidingstechniek op de voorkant van Analytical Chemistry
Onderzoekers van het Leiden/Amsterdam Centre for Drug Research en het Netherlands Metabolomics Centre hebben een van ’s werelds kleinste scheidingstechnieken weten te ontwikkelen door nanofluidische en elektrokinetische effecten te combineren. Vorige week verscheen hun onderzoek op de voorkant van het…
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Biomimetic redox reactions of the Cu(II) μ-thiolate complex
Promotor: Prof.dr. E. Bouwman
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Arjan de KoningWiskunde en Natuurwetenschappen
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Marc Koper ontvangt de Netherlands Catalysis and Chemistry Award
Marc Koper heeft de Netherlands Catalysis and Chemistry Award ontvangen tijdens de 20e bijeenkomst van de Netherlands' Catalysis and Chemistry Conference. ‘De ultieme kandidaat voor deze prijs’, zo valt te lezen in een van de aanbevelingsbrieven.
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Dr. Marcellus Ubbink benoemd tot hoogleraar Protein Chemistry
Dr. Marcellus Ubbink is dit voorjaar bij de Faculteit Wiskunde en Natuurwetenschappen benoemd tot hoogleraar Protein Chemistry. Ubbink kreeg in 2008 een Vici-subsidie van NWO.