Dit proefschrift omvat vier deelstudies naar de inhoud en structuur van de opvattingssystemen van natuurkundedocenten over het leren en onderwijzen van natuurkunde in het voortgezet onderwijs (VO) in Nederland.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Femke Bakker, Hawks and Doves: Democratic Peace Theory Revisited

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotor: S.M. Verduyn Lunel

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Promotie

Promotor: B. van de Water

Op 29 januari 2019 verdedigde Robbert van Eijk proefschrift 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. Het promotieonderzoek is begeleid door promotor prof. dr. H.J. van den Herik.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Promotores: W. Jiskoot, F. Ossendorp

What is the environmental impact of different waste collection systems across Europe? How can the collection be improved when considering collection, sorting, and treatment, as well as use options for secondary materials?

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. M. Ubbink

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.

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Promotie

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov