620 zoekresultaten voor “automated macromolecular structure solution” in de Publieke website
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Vertebrate automated screening technology (VAST)
Hoe kun je met robots en automatische herkenning van microscopische beelden uitzonderlijk snel het effect van medicijnen testen?
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Flexible updating of dynamic knowledge structures
Het artikel 'Flexible updating of dynamic knowledge structures' met bijdrage van Franziska Richter van Cognitieve Psychologie is uitgebracht door Nature.
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Research scientific programmer, Automated machine learning for spatio-temporal Earth Observation datasets
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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The structure of the cytochrome P450cam-putidaredoxin complex determined by paramagnetic NMR spectroscopy and crystallography
Promotor: Prof.dr. M. Ubbink
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Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Bad reduction of Hilbert modular varieties with parahoric level structure
Promotor: S.J. Edixhoven, A. Iovita
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A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
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Topologies and convergence structures on vector lattices of operators
This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.
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Structure and substructure in the stellar halo of the Milky Way
Promotor: K.H. Kuijken
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Galaxies and the structures in which they are embedded
Wetenschappers bij de Leidse Sterrewacht onderzoeken de fundamenteel natuurkundige verschijnselen die voor structuur in het heelal zorgen. Deze processen brengen materie bijeen tot sterrenstelsels en gas bijeen tot sterren. Met behulp van krachtige telescopen en geavanceerde berekeningen en computersimulaties…
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Solution for Critical Raw Materials - an European Export Network (SCRREEN)
Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.
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Exploring structure dependencies of gas-surface interactions with curved single crystals
Curved single crystals provide variable, but well-defined surface structures.
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Not so smooth after all: resolving dust and gas structures in protoplanetary disks
A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.
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Protoplanetary disk anatomy: examining the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Towards Photocatalytic Water Splitting in Homogeneous Solutions Using Molecular Metalloporphyrin Photosensitizers and Catalysts
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Transition metal compounds with S/N-functionalized NHC ligands: structures, redox properties and electrocatalytic activity
The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.
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isomorphisms, order antimorphisms and their interplay with Jordan algebra structures
In dit onderzoek worden orde isomorfismen en orde antimorfisme bestudeerd in het algemene kader van partieel geordende vector ruimten.
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Human-lion conflict around Nairobi National Park: Lion Population Structure, Diet, and Movement in a Semi-Fenced Park.
What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…
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Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
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Sex effects on development of brain structure and executive functions: Greater variance than mean effects
In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.
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oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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PhD candidate || Structure and dynamics in enzyme catalysis (1.0 fte)
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking strategies for
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Ruben Huele
Wiskunde en Natuurwetenschappen
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Aspects of Record Linkage
Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
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Computational optimisation of optical projection tomography for 3D image analysis
Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.
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Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
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Structured Parallel Programming for Monte Carlo Tree Search
The thesis is part of a bigger project, the HEPGAME (High Energy Physics Game). The main objective for HEPGAME is the utilization of AI solutions, particularly by using MCTS for simplification of HEP calculations.
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Crime and Crime Control: Structures, Developments and Actors
De eerste conferentie van de European Society of Criminology werd in 2000 in Lausanne gehouden. Nu, 16 jaar en veel nieuwe ESC-leden later, werd de 16e jaarlijkse conferentie van de European Society of Criminology gehouden in Münster van 21-24 september 2016.
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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Integrated life cycle assessment and life cycle costing of concrete recycling in the Netherlands
Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…
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Travelling patterns on Discrete Media
This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.
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Haye Geukes
Wiskunde en Natuurwetenschappen
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Meng Li
Wiskunde en Natuurwetenschappen
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Spectroscopy of two-field inflation
This thesis is about cosmological inflation and its relation to observations.
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Alexander van Oudenhoven
Wiskunde en Natuurwetenschappen