In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Joery Matthys, universitair docent aan het Institute of Security and Global Affairs, bracht begin deze maand een ex ante evaluatie van het Contraterrorismebeleid uit.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Kasteren

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

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Viabundus welcomes 10 minute-presentations about all kinds of research that could be performed with the aid of the Viabundus data, from experienced as much as early career researchers and students. Deadline: 9 September 2022.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

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Promotor: Prof.dr. M. de Jong

Promotores: W. Jiskoot, F. Ossendorp

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Friday 30 January 2015 were the final presentations of the last course of the Minor Sustainable Development.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Natuurkundigen hebben een astrofysisch neutrinosignaal van de IceCube detector bestudeerd vanuit een andere hoek. Het centrum van de Melkweg leek vanzelfsprekende de bron te zijn, maar deze hypothese is nu eerder verworpen dan bevestigd. Publicatie in Physical Letters B.

With Ad Putter, Sjoerd Levelt and Anne-Louise Avery. Based on William Caxton’s bestselling 1481 English translation of the Middle Dutch, but expanded with new interpretations, innovative language and characterisation, this edition is an imaginative retelling of the Reynard story. With its themes…

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Ancois de Villiers, PhD candidate at the Institute of Cultural Anthropology and Development Sociology, received the PeerJ Award for Best Student Presentation at the International Mediterranean Ecosystems Conference.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?

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This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotor: W. Jiskoot, Co-promotor: A. Kros

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

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Chemici, waaronder Sander van Kasteren en Hermen Overkleeft, hebben ontdekt dat azides, een bepaalde chemische verbinding, specifieke T-cellen kunnen laten reageren op een vaccin of juist het vaccin kunnen laten negeren. Publicatie in Angewandte Chemie.

Cardiovascular syndromes are the major cause of death in Western societies.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

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One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).