58 zoekresultaten voor “antibiotic resistance” in de Publieke website
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development
Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…
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Marcellus UbbinkWiskunde en Natuurwetenschappen
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Origins of antibiotic resistance
Lezing, Van Leeuwenhoek Lecture on BioScience
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Growth and Transport properties of (Rare Earth)TiO3 / SrTiO3 interfaces
This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Bètawetenschappers laten je het licht zien tijdens de Middag en Nacht van Ontdekkingen
Licht en donker, dat is dit jaar het thema van de Nacht van de Ontdekkingen van zaterdag 21 september op zondag 22 september 2019, in de Leidse binnenstad. Het programma belooft performances, lezingen, workshops en rondleidingen op het gebied van wetenschap, kunst en cultuur. Dit jaar is er voor het…
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Behandeling verbeteren voor pasgeboren baby’s met sepsis
De onderzoeksgroep van farmacoloog Coen van Hasselt heeft meegewerkt aan een studie die is gepubliceerd in het toonaangevende Lancet Infectious Diseases. Het internationale team bracht de behandeling met antibiotica van de levensbedreigende ontstekingsreactie sepsis bij pasgeboren baby’s in kaart in…
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Chemical Biology Lezing: Biosynthesis and Engineering of Cyclic Peptide Antibiotics
Lezing
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
Promotie
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Structural and biochemical analysis of antibiotic-target interactions
Promotie
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Rational empiric antibiotic therapy in clinical practice & policy making
Promotie
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Thrips resistance in Gladiolus: an eco-metabolomic approach
Promotie
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Combatting Clostridioides difficile: stress, adaptation and antimicrobial resistance
Promotie
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Research
The mission of our group is understanding how science communication works to improve the interaction between science and society.
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Diagnosis and treatment of obese children with insulin resistance
Promotie
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Systemic and adipose tissue inflammation in obesity and insulin resistance
Promotie
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotie
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Off the wall: characterisation and exploitation of a cell wall deficient life style in filamentous actinomycetes
Almost all bacteria are enveloped by a cell wall that provides cellular protection.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Mechanisms underlying the resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
Promotie
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
Promotie
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Studentenleven
Leiden is een echte studentenstad en heeft alles in huis om van jouw studententijd een onvergetelijke tijd te maken. Naast de vele studentenvereningen, zoals sport-, muziek- en gezelligheidsverenigingen, zijn er ook studievereningen, die gezellige evenementen organiseren voor jouw opleiding.
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EPIC Alliance bundelt krachten in strijd tegen antibioticaresistentie
Nee, dit gaat niet over een Star Wars Alliance die The Resistance wil onderdrukken. De EPIC Alliance brengt wetenschappelijke experts uit zeven landen samen om de toenemende dreiging van antibioticaresistentie aan te pakken. De Leidse hoogleraar Nathaniel Martin maakt deel uit van het elfkoppige con…
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Liveable planet lunch meeting - Duurzaamheid & Recht
Lezing
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Kirsten Leiss wint Jan Ritzema Bosprijs
Op 16 juni heeft Kirsten Leiss van de Universiteit Leiden de tweede Jan Ritzema Bosprijs gewonnen. Deze prijs werd door de Koninklijke Nederlandse Plantenziektekundige Vereniging (KNPV) uitgeloofd voor de beste presentatie van de dag, tijdens de voorjaarsbijeenkomst ‘Recente ontwikkelingen in de Gew…
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Research Technician – tumor cell biology
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Crimmigratie
Migratie en criminaliteit staan maatschappelijk volop in de schijnwerpers. Binnen het instituut voor Strafrecht en Criminologie heeft onderzoek op dit terrein zich de laatste jaren sterk ontwikkeld. Het begrip Crimmigratie staat daarbij centraal.
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Post-doctoral researcher
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
Promotie
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This Week’s Discoveries | 13 March 2018
Lezing