108 zoekresultaten voor “antibiotic resistance” in de Publieke website
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Dodelijke infecties nemen toe, nieuwe antibiotica hard nodig
Wereldwijd overlijdt een groeiend aantal mensen aan infecties omdat steeds meer bacteriën resistent worden tegen antibiotica. Nieuwe soorten zijn dringend nodig. Een veelbelovende resistentie-remmer wordt nu ontwikkeld door de onderzoeksgroep van Nathaniel Martin, hoogleraar Biologische chemie. Oratie…
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Origins of antibiotic resistance
Lezing, Van Leeuwenhoek Lecture on BioScience
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Metabolomic fingerprint biomarkers to guide antibiotic therapy and reduce resistance development
Ontwikkeling van resistentie tegen antibiotica kan optreden als patiënten onnodig of te lang met antibiotica behandeld worden. Diagnostiek waarmee snel een bacteriële infectie vastgesteld kan worden, of de response op antibiotica bepaald kan worden, zijn daarom belangrijk om therapie te optimaliseren…
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This Week’s Discoveries | 2 October 2018
Lezing
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Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Promotie
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
Promotie
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Diagnosis and treatment of obese children with insulin resistance
Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Bètawetenschappers laten je het licht zien tijdens de Middag en Nacht van Ontdekkingen
Licht en donker, dat is dit jaar het thema van de Nacht van de Ontdekkingen van zaterdag 21 september op zondag 22 september 2019, in de Leidse binnenstad. Het programma belooft performances, lezingen, workshops en rondleidingen op het gebied van wetenschap, kunst en cultuur. Dit jaar is er voor het…
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Signalling pathways that control development and antibiotic production in streptomyces
Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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This Week's Discoveries | 10 December 2019
Lezing
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Van Leeuwenhoek Lecture on BioScience: DNA Sequencing Technology
Lezing
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Rational use of antibiotic
Promotie
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Artistic Research in Music: Discipline and Resistance - Artists and Researchers at the Orpheus Institute
Publicatie boek 'Artistic Research in Music: Discipline and Resistance' markeert 20-jarig jubileum Orpheus Instituut.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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TechTalk: Infectious Diseases
Lezing
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LUCIR lezing: The Power of Civil Resistance
Lezing
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Chemical Biology Lezing: Biosynthesis and Engineering of Cyclic Peptide Antibiotics
Lezing
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The Global Challenge of Antimicrobial Resistance
Lezing, Studium Generale
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Signalling pathways that control development and antibiotic production in Streptomyces
Promotie
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Diagnosis and treatment of obese children with insulin resistance
Promotie
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotie
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Insulin resistance and atherosclerosis: the role of visceral fat
Promotie
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Systemic and adipose tissue inflammation in obesity and insulin resistance
Promotie
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Promotie
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insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
Promotie
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
Promotie
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Mechanisms underlying the resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
Promotie
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Ghosts Here and There: Spectral Resistance and the Ethics of Ghosts in Postcolonial Literature
Promotie
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This Week’s Discoveries | 16 February 2016
Lezing
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Wetenschap en bedrijfsleven werken samen aan alternatieven voor antibiotica
Bijna vijftig wetenschappers en twintig bedrijven gaan werken aan de ontwikkeling van nieuwe antibiotica en alternatieven voor antibioticagebruik. NWO investeert samen met het ministerie van VWS bijna 7 miljoen euro in het onderzoeksprogramma. Ook wetenschappers van de Universiteit Leiden en het LUMC…
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Online Book Presentation: Reynard the Fox, retold by Anne Louise Avery
With Ad Putter, Sjoerd Levelt and Anne-Louise Avery. Based on William Caxton’s bestselling 1481 English translation of the Middle Dutch, but expanded with new interpretations, innovative language and characterisation, this edition is an imaginative retelling of the Reynard story. With its themes…
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