This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Promotores: W. Jiskoot, F. Ossendorp

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: A. Kros

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotor: A. Kros

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Do sustainability values play a role in motivating people to act for biodiversity in successful projects and in successful leadership action? And how could these values be incorporated in current economic valuation methods?

Promotores: Wim Jiskoot; Ferry Ossendorp

Matthias Barz is benoemd tot hoogleraar Biotherapeutics delivery bij het Leiden Academic Centre for Drug Research (LACDR).

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

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Promotor: B.van de Water, Co-promotor: L.S.Price

What is the best way to combine the environmental and economic data and how can we create an operational system to do so, thereby supporting the delivery of data to the Data centres on Products and Resources?

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

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Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

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How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?

Comparing the global warming potential (GWP) of the service provided by an iRex Digital Reader to the same service provided by an office printer using a scanning LCA.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Development of GHG calculator for bio-electricity and heat.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

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Students Practicing Citizen Journalism

Evaluating the environmental consequences of diet changes in the European Union.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.