2,350 zoekresultaten voor “agent based modelling” in de Publieke website
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Exploring and exploiting activity-based protein profiling in chemical biology and medicinal chemistry
Overkleeft
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Therapeutic Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Construction and exploration of modular goldnanoparticles for glycan-based immune-interventions of worm infections
Chiodo
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach
Op 7 mei 2020 verdedigde Jolanda van der Vliet proefschrift 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.J. Schrijver en prof.dr.ir. J.J.C. Voorhoeve.
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Impact assessment modelling of matter-less stressors in the context of Life Cycle Assessment
Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs
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Distance-based analysis of dynamical systems and time series by optimal transport
Promotor: S.M. Verduyn Lunel
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Gaining control of lipid-based nanomedicine by understanding the nano-bio interface
Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…
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Ik laat de hoe-vraag over aan de agenten zelf
Jaarlijks begeleidt Arthur van Baaren (districtschef Leiden-Bollenstreek) een LLP-studententeam en werkt hij samen met hen aan een praktijkopdracht. Vanuit zijn functie laat hij de studenten zien wat leiderschap inhoudt en hoe hij daar bij de politie vorm aan geeft. “Ik probeer over te brengen wat ik…
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Gintingan in Subang: An Indigenous Institution for Sustainable Community-Based Development in the Sunda Region of West Java, Indonesia
This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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Peter van BodegomWiskunde en Natuurwetenschappen
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Identification of novel targets in prostate cancer progression
Promotor: B. van de Water, Co-promotor: E.H.J. Danen
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RiskCycle: Risk-based management of chemicals and products in a circular economy at a global scale
How can we, together international experts, define future needs of R+D contributions for innovations in the field of risk-based management of chemicals and products in a global perspective using alternative testing strategies to minimize animal tests?
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A monodromy criterion for existence of Neron models and a result on semi-factoriality
In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
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Gerard van Westen: 'Ons model voorspelt wat kandidaat-medicijnen doen in je lijf'
Hij praat snel en enthousiast. Logisch, want Gerard van Westen is als de machinist op een heel snelle trein. Het eindstation: een virtuele mens, bestaand uit algoritmen die voorspellen wat een toegediende stof doet in ons lichaam. De trein is al een heel eind op weg. De farmaceutische industrie is ook…
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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Post-doctoral researcher, Chip-based platform for exploring the interface between quantum mechanics and general relativity
Wiskunde en Natuurwetenschappen, Leids Instituut voor Onderzoek in de Natuurkunde (LION)
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Honoursstudenten op veldonderzoek: ‘Agenten kunnen beter geen TikTokdansje doen’
Interviews afnemen met scholieren en brainstormen met rechters en advocaten. Studenten van het honoursvak Vertrouwen in de Rechtstaat ontdekten hoe scholieren van het Haagse Edith Stein College denken over instituties en hoe recht uitpakt in de praktijk.
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Astrophysical plasma modeling of the hot Universe: Advances and challenges in high-resolution X-ray spectroscopy
Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
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Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation
Op 6 juni 2019 verdedigde Edward Donelan zijn proefschrift 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. Het promotieonderzoek is begeleid door promotor prof. W.J.M. Voermans.
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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Marieke Liem in BN DeStem over de moordzaak van agent Wendell C
Op maandag 9 september heeft politieagent Wendell C (Dordrecht) zijn twee kinderen en zichzelf doodgeschoten. De moeder werd ook neergeschoten en overleed die nacht in het ziekenhuis. Marieke Liem, Universitair hoofddocent aan het Insitute of Security and Global Affairs (ISGA), praat over het delict…
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signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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in De Volkskrant en Trouw over het geklungel van Russische geheim agenten
Ben de Jong, gastonderzoeker op het gebied van inlichtingendiensten bij het Institute of Security and Global Affairs wordt in de Volkskrant en Trouw geciteerd over de vraag of Russische geheime diensten zitten te klungelen. Aanleiding zijn meerdere blunders de afgelopen tijd, keer op keer laten de geheim…