This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Overkleeft

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

De verhoogde activatie van het striatum, die adolescenten laten zien bij beloning, wordt meestal in verband gebracht met risicogedrag en negatieve gezondheidseffecten. In dit artikel in Nature Communications wordt een mogelijke positieve kant van die verhoogde activatie onderzocht. De activatiepiek…

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Promotor: Prof.dr. G.P. van Wezel

Science Based Business (SBB) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve maatschappelijke…

Science Based Business (SBB) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve maatschappelijke…

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: K.J. Batenburg

Promotor: Prof.dr. H.A.G. Wijshoff

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

ICT Shared Service Centre

ICT Shared Service Centre

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Met dit project wordt onderzocht hoe docenten op drie internationale scholen zich gezamenlijk professionaliseren rond het thema ‘Inquiry based teaching’. Gegeven de rijkdom aan ervaring en achtergronden van de docenten op internationale scholen, kan worden verwacht dat docenten veel kunnen leren…

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Promotor: S.M. Verduyn Lunel

Promotor: Prof.dr. M. Danhof

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

In dit proefschrift wordt de samenwerking tussen studenten en resultaten in online projectgestuurd hoger onderwijs in China onderzocht.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Meer informatie over dit onderzoeksproject vind je op de Engelstalige pagina.

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Promotor: Prof.dr. J. Kuiper

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)