Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotor: B.van de Water, Co-promotor: L.S.Price

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

Promotor: Prof.dr. E. Deprettere

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: Prof.dr. V. Icke, Co-Promotor: T.I. Madura

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Peter Grunwald

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Synthetic microswimmers take an important place within the interdisciplinary field of active soft matter.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

De Leidse promovendus Sreenivasa Ramaiahgari ontwikkelde voor het eerst een 3D-model van de lever. Zijn model kan een hoop besparen: schade bij patiënten, dierenleed en veel geld. Promotie 4 juni.

Promotor: Prof.dr. W.J.G.M. Peijnenburg

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: Prof. dr. A.G.G.M. Tielens

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Promotor: Prof.dr. F. den Hollander, G.Maillard

Promotor: P.D. Grünwald

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Botonderzoek levert veel gedetailleerde gegevens op over de gezondheid van een persoon of van een groep. Die gegevens worden gebruikt om het verleden te reconstrueren, maar ook om ziektes van nu te bestrijden.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Vier Leidse studenten die de masterspecialisatie Science Based Business volgen, bedachten een concept om met een 3D Bioprinter menselijke huid te produceren. Slachtoffers van brandwonden zouden dankzij Skinprint minder operaties nodig hebben en er minder littekens aan over houden.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Promotor: Prof.dr. B.R. Katzy