Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

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Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Op donderdag 26 januari 2017 verdedigt Anouk Bosma haar proefschrift ‘Targeting recidivism: An evaluation study into the functioning and effectiveness of a prison-based treatment program’. Promotor is prof. dr. Paul Nieuwbeerta, en copromotor dr. mr. Maarten Kunst.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Promotie

Op 27 mei 2021 verdedigde Hirad Abtahi zijn proefschrift 'Adjudicating Attacks Targeting Culture'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

Promotie

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

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Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

During the course of drug discovery translational steps are made.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

Op donderdag 26 januari 2017 verdedigt Anouk Bosma haar proefschrift ‘Targeting recidivism: An evaluation study into the functioning and effectiveness of a prison-based treatment program’. De verdediging begint om 15.00 uur, in het Academiegebouw van de Universiteit Leiden, Rapenburg 73. Promotor is…

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Na de aanslag op 22 mei 2017 in Manchester Arena komt de term 'soft target' nu vaak voorbij. Jeanine de Roy van Zuijdewijn, onderzoeker verbonden aan het Institute of Security and Global Affairs, heeft deelgenomen aan een Q&A over de aanslag in Manchester.

Project TARGET is een onderzoek gericht op de relatie tussen illegale vuurwapenhandel en vuurwapengeweld. In een studie in zeven landen werd gekeken naar de verschillen en overeenkomsten. Katharina Krüsselmann en Marieke Liem namen de situatie in Nederland onder de loep. In dit artikel hun belangrijkste…

Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.

What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

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This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

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Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Promotor: Prof.dr. J.N. Kok

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotie

In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.

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In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.