An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Prof. Elizabeth de Lange is concerned with the allocation of resources for the conduct of science towards the goal of best serving the public interest. Also, while she underscores that there is still the need for using animals in drug research, she is concerned about this use, and advocates the use…

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Supervisor: Gerard van Westen

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Alternatives to current practice

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Researchers of the Leiden Institute of Advanced Computer Science (LIACS) have started a 4 year project on developing a system that sends out automatic alerts when components from engines are showing first signs of fatigue.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

ASLU 14

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

A research agenda

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Is is possible to better predict the validity of drug candidates?

The project XAIPre (pronounce “Xyper”) aims to develop predictive maintenance system for the maritime industry using sensor technology and artificial intelligence. The project aims at developing Explainable Predictive Maintenance (XPdM) algorithms that do not only provide the engineers with a prediction…

Are predictive archaeological maps a reliable tool to play an important role in the spatial planning? One of the goals of this project was to develop best practices for the production and application of the models.

In this work, we attempt to answer the question:

A chair tipping over serves as a metaphor for a migraine attack in Thijs Perenboom’s PhD research at Leiden University Medical Center (LUMC). He wants to unravel whether and how we can predict migraine attacks. He will defend his thesis on Tuesday 21 June.

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

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On 27 May 2021, Hirad Abtahi defended his thesis 'Adjudicating Attacks Targeting Culture'. The doctoral research was supervised by Prof.dr. C. Stahn.

Efficient gene-targeting during meiosis

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

How to come to valid risk stratification of alcohol use disorder?

Research goal: To support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be…

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Promotor: P.D. Grünwald

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Discovery of metastasis promoting candidate drug targets

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Honorata Mazepus and Jaroslaw Kantorowicz are assistant professors at the Institute of Security and Global Affairs. Mazepus and Kantorowicz are one of the authors of this article in Nature on the role of national identity on public health support during global pandemics.

Promotie

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

The work of judges can also be done by AI systems. These systems can formulate an objective proposal for a ruling. But such proposal should always be checked by a judge, says Bart Custers.