388 zoekresultaten voor “target engagement” in de Publieke website
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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Targeting intraplaque angiogenesis: imaging and therapeutic interventions
Promotie
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Promotie
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Harnessing placebo effects by targeting expectancies
Promotie
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Gamechangers
Onderzoek naar het ontwikkelen van privacy-vriendelijke zorg-games voor kinderen.
- Academic English online for Secondary School Students
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Engagement politique et conditions des acteurs de l’économie informelle
Promotie
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
Promotie
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Sterrenkijkende toeristen: Leidse Sterrewacht lanceert handleiding voor astrotoerisme
Hoe creëer je een onvergetelijk astronomie-uitje voor toeristen? En hoe zorg je voor leuke activiteiten die ook nog eens educatieve waarde hebben? De Astronomy & Society groep van de Leidse Sterrewacht heeft een handleiding vertaald die deze vragen beantwoordt. Het team hoopt op deze manier het grote…
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Exploring Grainyhead-like 2 target genes in breast cancer
Promotie
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Mechanisms of melanoma-targeting antibody therapy in mice
Promotie
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Regulation of Target Proteins by Small Ubiquitin-like Modifiers
Promotie
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Structural and biochemical analysis of antibiotic-target interactions
Promotie
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Chikungunya virus nonstructural protein 1 as an antiviral target
Promotie
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Inflammation as a target for treatment in hand osteoarthritis
Promotie
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Targeting of antigen-presenting cells with mannosylated conjugates
Promotie
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Targeting HLA Class II in allogeneic stem cell transplantation
Promotie
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Spatiotemporal building stock modeling for residential decarbonization in the Netherlands
Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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Ruthenium-peptide conjugates for targeted phototherapy
Promotie
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UITGESTELD | Targeting of antigen-presenting cells with mannosylated conjugates
Promotie
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Random walks on Arakelov class groups
The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.
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The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
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Key Teams and Contact Emails
Moet je contact opnemen met LLInC? Stuur ons gewoon een e-mail - hello@llinc.leidenuniv.nl - of kijk hieronder voor contactgegevens per team.
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Astronomie door een speldengaatje
Je kan prachtige plaatjes schieten met alleen een gat in een doos. Geïnspireerd door de viering van Leiden als Europese stad van de wetenschap, plaatste hoogleraar Matthew Kenworthy in 2021 verschillende gaatjescamera’s bij de Oude Sterrewacht. Dit is hoe de simpelste apparaten de grootste patronen…
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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NeCEN
Met de krachtige elektronenmicroscopen van NeCEN bestuderen we afwijkingen aan cellen van bloedvaten bij hart- en vaatziekten, de wisselwerking tussen ziekteverwekkers en gastheren bij infectieziekten, moleculaire processen die kanker veroorzaken, de interactie tussen geneesmiddelen en target-eiwitten.…
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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SiTaSol
What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?
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Museum in the Caribbean: Grassroots Heritage Initiatives and Community Engagement
Promotie
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Doing the Right Thing in Science: A History of a Moving Target
Lezing, Keynote
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Determinants of genome editing outcomes: the impact of target and donor DNA structures
Promotie
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The replication machinery of Clostridium difficile: a potential target for novel antimicrobials
Promotie
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In vitro models of bone-forming tumours: from target to treatment
Promotie
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Targeting glycolysis in endothelial cells to prevent intraplaque neovascularization and atherogenesis in mice
Promotie
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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The NKG2A / HLA-E axis a novel target for immune checkpoint therapy
Promotie