During stepwise synthesis of sugar chains, two stereometric variants are formed at each step unless the steps are steered. Through an extensive investigation, Daan Hoogers investigated a new steering mechanism, for which he was nominated for the Young Star Award 2021.

PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

When following a course on archaeology of the Crusaders, five archaeology students were presented the unique opportunity to create a small exhibition at the National Museum of Antiquities. The coronavirus situation made a complex task even more challenging. ‘We had to work through the lockdown with…

Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.

Although sugars are widely used in biological and medical research, their synthesis is still badly understood. Jeroen Codée has received a Vici grant of 1.5 million euros for systematically studying the production of sugars. ‘I want to genuinely understand the reactions.’

At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…

Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Thomas Hansen is our Leiden Institute of Chemistry's nominee for the C.J. Kok Jury Award 2020.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

The journey of sugar from east to west

Promotie

Promotie

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.

Painstaking research in Dutch and Portuguese archive materials, so far poorly assessed on the topic of social relations, reveals intense and intricate associations between different European individuals both in terms of ethnicity and social strata.

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Promotor: H.V.J. Linnartz

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Corrie Bakels & Hans Kamermans (eds) (2009)

Through extensive archaeological and documentary research, this study aims to provide a detailed analysis of the maritime cultural landscape of St. Eustatius over the past four centuries. It focuses on bridging the gap between the marine and terrestrial worlds and demonstrates that in order to truly…

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

What does it mean to eat healthily and responsibly? This question is gaining a new urgency now that in many countries undernourishment is being overtaken by diseases of affluence, such as obesity, and we are also becoming more aware of the environmental impact of our eating habits. It’s time to take…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Archaeological and related essays on the Jordan Valley in honour of Gerrit van der Kooij on the occasion of his sixty-fifth birthday

How and why latex bearing plants select specific chemical compounds for eco-chemical interactions with its biotic factors?

A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

In science, it is of vital importance that multiple studies corroborate the same result. Researchers therefore need to know all the details of previous experiments in order to implement the procedures as exactly as possible. However, this is becoming a major problem in neuroscience, as animal studies…

Research at the THEOR group is comprised of the following research themes:

The

Marten Soolmans (1613-1641) studied law in Leiden at the same time that Rembrandt lived in the city. Rembrandt painted Soolmans and his wife Oopjen in 1634, after all three had moved to Amsterdam. This remarkable portrait of the sumptuously dressed Soolmans can be seen at the Kamerlingh Onnes Building,…

Leiden chemists, together with colleagues at the University of York (UK) and Technion (Israel) have discovered a small, sugar-like molecule that maintains the integrity of tissue around a tumour during cancer. This molecule prevents tumour cells from spreading from the primary cancer site to colonise…

How has landscape and land use changed in these two case studies since independence? What has caused these changes, whether anthropogenic or natural? How do local communities in the areas of study perceive these changes? How can community knowledge be integrated with mapping tools (GIS) to contribute…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.