In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

With tomography it is possible to reconstruct the interior of an object without destroying.

Promotor: K.J. Batenburg

Promotor: Prof.dr. K.J. Batenburg

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

On 8 July, the symposium 'The digital reconstruction of the crucifixion of the Lindau master (ca. 1425)' will take place at the auditorium of Museum Catharijnecovent, from where it will also be broadcasted online.

Promotores: R. Tijdeman, K.J. Batenburg

Promotores: K.J. Batenburg, B. Koren

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

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Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

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The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

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Taalkundige Marian Klamer, verbonden aan het Leiden University Centre for Linguistics en het Leiden University Institute for Area Studies, is een van de 31 wetenschappers die van het NWO een Vici-subidie gekregen heeft voor haar onderzoeksproject 'Taal als tijdmachine'.

Promotor: Prof.dr. P.C. van Welzen

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: Prof.dr. E. Smets, M. Stech

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

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Live meekijken met een CT-scan in plaats van achteraf de beelden pas te analyseren. Als het aan de Leidse wiskundige Jan-Willem Buurlage ligt, is dat binnenkort realiteit. Hij ontwikkelt methodes om de algoritmes achter 3D-scans sneller te maken. Best een uitdaging: ‘Net als wiskundigen zijn computers…

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Rachel Schats is Assistant Professor in Human Osteoarchaeology in the Faculty of Archaeology, Leiden University.

In this dissertation non-parametric Bayesian methods are used in the application of robotic vision.

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Afgelopen week werd bekend dat Juliëtte Roding (LUCAS) en Odile Parsis (Université de Lille, Institut de recherches historiques du Septentrion) van de Frans-Nederlandse Academie een Van Gogh-grant hebben ontvangen voor het multidisciplinaire onderzoek: 'North(s) in Memory: Heritage, Museum dynamics…

Big celebration upcoming weekend: MIRD's 20th anniversary is on the cards. Four alumni from different periods tell what this unique two-year master's in International Relations and Diplomacy has brought them.

Een internationaal team van onder meer Leidse onderzoekers heeft aangetoond dat er een verfijndere methode is om oude microbiomen te bestuderen. Dat helpt archeologisch onderzoek naar de effecten van Europese kolonisatie in de Caraïben. Publicatie in Nature Scientific Reports op 13 november.