How can ecosystem services within river catchments be quantified in spatial and temporal explicit way?

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

The main topic of the book is the nature of inner aspect of the Verb Phrase, and the relation between the decompositional and the quantificational approaches to this problem.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Research project 'QUAD'

Promotie

This dissertation provides a novel perspective on the interaction between quantifier scope and ellipsis. It presents a detailed investigation of the scopal interaction between English negative indefinites, modals, and quantified phrases in ellipsis. One of the crucial observations is that a negative…

Promotie

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

Promotie

The potential of bioneedles to deliver influenza vaccines was investigated.

Lezing

Principles of Functional Analysis applied to Dutch Neolithic Assemblages.

Dr at CAMAG Laboratory, Switzerland

The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.

Lezing

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

In 2021 we will start with a weekly lunch time seminar series, online on Mondays from 12 noon onwards.

Promotie

An important hormone excreting gland in the human body is the pituitary

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

Simulating human language understanding on the computer is a great challenge. A way to approach it is to represent natural language meanings in logic, and to use logical provers to determine what does and does not follow from a text. What logic is best to use and how natural language meanings are best…

The Bioinformatics and Genomics Core provides bioinformatics advice and genotyping services. The researchers that lead and work for this facilities are experts in their fields and are available for consultation regarding experimental design and interpretation of results.

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

Schneider

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

The aim of the division of Systems Biomedicine and Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

SAILS organises regular events such as symposia, webinars and workshops. We are organising virtual meetings until further notice.

Promotie

Knowledge and culture subproject 4:

How do nanoparticles bioaccumulate and biodistribute in organisms?

This part of the research programme is carried out by Prof. Dr. René Cappers. It focusses on the continuities and changes in the use of plants at Late Neolithic Tell Sabi Abyad, as well as on their implications as proxy evidence for the climate change c. 6200 BC. Parallel to the design of the other…

Research project ‘Quantification, Administrative Capacity, and Democracy (QUAD)’ has a vacancy for a postdoc.

Students searched for MSc Internships under the following topics: 1. Understanding temporal variability in functional biodiversity and 2. Characterization of engineered nanoparticles in aquatic organisms: Gold nanoparticles and carbon nanotubes

SAILS organises regular events such as symposia, webinars and workshops. We are organising virtual meetings until further notice.

This week, the Dutch Cancer Foundation (KWF) has awarded two research grants to LUMC researchers that include the development of advanced AI technology to improve and personalize oncological treatment.

To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?

The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.

With the aid of artificial intelligence (AI), care professionals at the LUMC (Leiden University Medical Center) are able to calculate quickly and accurately whether a coronavirus patient has suffered serious lung damage. They do this by putting a CT scan through the AI software of the CAD4COVID-CT p…

Lezing