Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

What are the values that Leiden University cherishes? What does the University stand for and what does it consider important?

The philosophers at the Institute of Philosophy develop new perspectives and insights not only on fundamental philosophical questions, but also on topical and interdisciplinary themes such as secrecy, migration, and climate change.

Since its beginning, Leiden University has been one of Europe's leading international research-intensive universities.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

An important hormone excreting gland in the human body is the pituitary

Students are educated to become academic professionals and responsible and engaged citizens who are internationally and interculturally competent

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

The reintegration of high profile ex-offenders frequently receives great political and public attention. While this attention, more often than not in the form of negative sentiments, may be understandable from a moral perspective, it raises several important questions: how do such offenders reintegrate…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Supervisor: Anna Vlachodimou

Politically speaking, the Frisian coastal area constitutes a special case in late medieval Europe since it was not subject to an overlord as it withstood feudalization in the 13th century. Its many sub regions, which were dominated by elites of small noblemen and freeholders, long time succeeded in…

Due to the fact that the Frisian lands lacked major political centers in the Middle Ages and also because most of its monasteries suffered complete destruction in the second half of the 16th century, relatively few written documents concerning medieval Frisian history have survived. To analyze them…

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…

Supervisor: Maarten Doornbos

The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Since my master's thesis on the landed property of the Frisian monasteries in the Middle Ages I am highly interested in the do ut des-aspects of the relation between religious houses and the lay world. Key words here are: property, power, patronage and the role of religious institutions in the 'salvation…

Abdessamad El Amraoui defended his thesis on 6 Mai 2015.

How are digital risk-profiles developed and used in practice?

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Supervisor: Andrea Martella

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

The narrow but long stretched stript of Frisian land along the North Sea was already occupied before Roman times. However, man repeatedly suffered setbacks when he tried to extend his living space, both in the tidal marshes and the peat area south of them.

Fighting for the faith, caring for the sick, and praying for the soul of their benefactors were the main tasks of the military orders, who since the time of the crusades were well represented in the Netherlands in the Middle Ages, including the Frisian lands. Especially the Hospitallers and the Teutonic…

Historical geo data are gaining in importance. Provided that they are exactly geo referenced, they can be stored into a GIS and thus be combined with all kinds of maps (topographical, pedological, etc.) and datasets. This makes it possible to analyze historical developments in space and time on a detailed…

Schools of secondary education are assigned to (further) develop a curriculum vision regarding three functions of education (Sectorakkoord VO, 2014; 2018).: qualification, socialization, and subjectification (Biesta, 2015). This research project is aimed at developing instruments that help schools identify,…

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Leiden University Library and related museum holdings in Leiden contain a body of materials showing the unique role of Dutch-Japanese trade relations as a node in the history of global flows of knowledge, materials and culture during the early modern period.

How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

Our society can no longer not imagine the threat of cybercrime. Banks, companies, and schools are hacked, or 'DDoSed', with increasing regularity and data is being stolen or taken hostage. To respond adequately to this threat, we need more knowledge of the perpetrators.

Victims of ethnic profiling have commenced legal proceedings against the Royal Netherlands Marechaussee. Peter Rodrigues, Professor of Immigration Law, says in a national newspaper that ethnicity may never be the most important criterion to stop and question a person and refers to a past ruling by the…

This week the regional court in The Hague gave a ruling that has attracted international attention. The State of the Netherlands (Ministry of Social Affairs) was taken to court by two famous writers, Wieringa and Februari, several NGOs and a trade union.

Bringing together institutes and research groups, how do you do that? The Faculty of Science set up a joint research theme and financed three PhD positions. After four years, the profiling programme Endocannabinoids expires. ‘It really brought us together, and the collaborations remain.’

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Two new Assistant Professors are joining Science Based Business (SBB) this Autumn. ‘Xishu Li and Jian Wang are the first two Assistant Professors we recruited. This is an exciting, crucial next step for SBB,’ said Professor Simcha Jong who joined Leiden University as the Director and first Professor…

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Two citizens, together with organisations including Amnesty International, antidiscrimination agency RADAR and the Dutch Section of the International Commission of Jurists (NJCM) have brought legal action against the State. They want the court to put an end to the discriminating border controls of the…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.