Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

2 joint initiatives began in 2019 which attempt to connect the various efforts around active learning at Leiden University: the active learning network, and the Saltswat project.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

This project will explore how Chinese digital networks are grounded in real-world institutions, and how interest groups and individuals use digital infrastructures to shape public discourse on national history.

A Diachronic Perspective on the Aegean

Promotor: F. Arbab, R. De Nicola, Co-Promotor: M. Tribastone

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: Prof. dr. A.G.G.M. Tielens

Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…

Source: J Cheminform, Volume 7, Issue 1 (2015)

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

The objective of this project is the development of a new psychometric model, called the Generalized Squared Distance Logistic Model (GSDLM). This model is an evolution of older psychometric approaches (such as PARELLA, GHCM, and GGUM) and the Gaussian Ordination Models (GOMs) used in environmental…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Promotor: P.D. Grünwald

Promotor: Prof.dr. F. den Hollander

The proposed research project examines the social role of two monk-bishops in seventh-century Egypt, Abraham of Hermonthis and Pesynthios of Koptos, by reconstructing their social networks on the basis of their archival documents.

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.

Wiskunde en Natuurwetenschappen, Mathematisch Instituut (MI)

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.

This dissertation addresses the different use of the same philosophical model: immanent teleology. In this work Aristotle, the founder of the study of final causes, is put in relation with the modern French evolutionary thinker Henri Bergson, the philosopher of time. The dissertation tackles the two…

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics. The network is embedded in the Leiden Centre of…

Alumni-activiteit

What is “teaching excellence” in Higher Education? Which different teaching excellence training, promotion and reward schemes exist across Europe? How can a common European teaching scheme look like? The e-NOTE project led by Leiden University seeks to answer these question in cooperation with five…

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Promotores: J. Kok, M. Chaudron (Chalmers University)

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotor: Prof.dr. G.R. de Snoo, Co-promotores: Dr. ing. M.G. Vijver, J.P.M. Vink

Material Crossovers

This thesis is divided into two parts. In Part I we study metastability properties of queue-based random-access protocols for wireless networks. The network is modeledas a bipartite graph whose edges represent interference constraints. In Part II we study spectra of inhomogeneous Erdős-Rényi random…

What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?

The role of transnational, non-institutional networks in the opening up of British transatlantic trade at the end of the 17th/beginning of the 18th century

Intelligence of the crowd, or in other words, intelligence of a large, random collective, exists mostly in social media platforms such as twitter. The collective does not comprise (at least not necessarily) experts on crises, just regular people mostly. Nevertheless, there is valuable intelligence to…

Dr. Cátia Antunes and prof. Jos Gommans both edited and contributed to this interesting book, that consists of articles that offers a new insight into the macro and micro worlds of the global Dutchman in Asia.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

Recent concerns about cultural identity emphasise the ongoing political and social importance of the question of how, and with whom, people identify. Changing and conflicting identities were highly relevant for pre-modern Europe. Paradoxically, the more powerful states became, the more their rulers…