In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotie

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Our response to stress is regulated by the ‘bliss molecule’ anandamide but how exactly remained unknown. Until recently, that is. Elliot Mock has now succeeded in developing a new substance that reduces anandamide, called LEI-401. This has made it easier to conduct research into the role of anandamide…

Overview of Molecular Physiology publications