By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.  

Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

The old dummy MRI scanner in the LUMC was replaced by a 'new' one from Marktplaats (!) at the beginning of July 2020. This device is used specifically for children and adults suffering from claustrophobia, and to introduce the elderly to the scanner.

A new NMR microscope gives researchers an improved instrument to study fundamental physical processes. It also offers new possibilities for medical science, for example to better study proteins in Alzheimer patients’ brains. Publication in Physical Review Applied.

The updated MRI scanner at the Leiden Institute for Brain and Cognition (LIBC) will become operational on 29 September. The new version is faster and better than the current model.

In October 2019, OSCL organised a Hackathon on the ins and outs of MRI datasharing

Kan artificiële intelligentie (AI) helpen om subtiele veranderingen in de gewrichten op te merken op MRI-beelden van patiënten met reumatoïde artritis? Die vraag gaan Leidse wetenschappers beantwoorden dankzij een subsidie van de Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO).

Researchers from Leiden, in cooperation with Philips, have won a challenge in which international research groups dedicate themselves to accelerating MRI scans with the help of artificial intelligence (AI). They developed an algorithm with which it is possible to use eight times less data than normal…

Professor Andrew Webb has been appointed Simon Stevin Master 2017 by the Netherlands Organisation for Scientific Research, an award that carries a prize of 500,000 euros. Webb, who is Professor of MRI Physics at Leiden University Medical Center (LUMC), will use this funding to focus on developing new…

Een samenwerking tussen het Leids Universitair Medische Centrum (LUMC), de Universiteit Leiden en Philips ontvangt financiering van wetenschapsfinancier NWO om MRI-scans te versnellen. Deze drie partijen vormen samen een van de 17 AI-labs die onder de naam ROBUST voor een periode van 10 jaar NWO-steun…

Together, Leiden University Medical Center (LUMC), Leiden University and Philips are one of the 17 AI labs within the ROBUST consortium that will receive support from the Dutch Research Council (NWO). The aim of this collaboration is to use artificial intelligence to speed up MRI scans.

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

This dissertation examines what network in the human brain is involved in the perception of prosody and whether activity within this network is modulated by the personality trait alexithymia.

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Research facilities within reach of LIBC members:

‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

There have been indications for decades that there is a link between increased iron levels in the brain and Alzheimer’s disease. Leiden physicists find this connection as well, thereby now making a distinction between different forms of iron. They identify specific iron forms that increase in Alzheimer’s…

Just imagine: you see someone being treated unfairly. Do you find it more rewarding to help the victim or punish the perpetrator? Research by Leiden psychologist Mirre Stallen indicates that punishing is more rewarding. Publication in JNeurosci.

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

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Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

With his ice-cold nano force sensor, Tjerk Oosterkamp searches for the boundary between the quantum world and the everyday world. The Leiden physicist has received an NWO subsidy of 600,000 euros.

We explore the possibilities to combine magnetic resonance techniques with atomic force microscopy together in a single microscope: the MRI-AFM, also called Magnetic Resonance Force Microscopy (MRFM).

How do practice and theory reinforce one another in neuroscience? Professor Birte Forstmann’s inaugural lecture on 2 October will be about building interdisciplinary bridges between cognitive neuroscience and cognitive models. Her approach may lead to brain research with fewer side-effects for patie…

An MRI scanner is much more than a machine alone. It is an extremely versatile technique that provides numerous opportunities for finding out more about the workings of the human brain, says Thijs van Osch, Professor of Radiology, with a particular emphasis on experimental cerebrovascular imaging. Inaugural…

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How can we develop a new microscope that can distinguish individual atoms in proteins?

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