How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.

Promotie

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

Promotor: A.P. IJzerman

An international group of scientists, led by Leiden physicist Sense Jan van der Molen, has developed the first switchable molecular diode. You can turn this on and off through humidity. Vice versa, it is a humidity sensor at the nanoscale. Publication on 4 December in Nature Nanotechnology.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

Special amplifying agents can make MRI scanners and NMR techniques hundreds of times more sensitive. Leiden physicists have now found a method to test their efficiency. More sensitive MRI scans could for example improve our understanding of cystic fibrosis or Parkinson’s disease. Publication in PCCP…

Lezing

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

Cars are equipped with catalysts to disarm toxic exhaust gases. Platinum plays an important role there. Leiden physicists and chemists have now for the first time seen the mechanism behind a platinum catalyst. With a fundamental understanding of the process, scientists can use this rare material more…

We are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Our response to stress is regulated by the ‘bliss molecule’ anandamide but how exactly remained unknown. Until recently, that is. Elliot Mock has now succeeded in developing a new substance that reduces anandamide, called LEI-401. This has made it easier to conduct research into the role of anandamide…

In the master's specialisation Life Science Research and Development students will learn to understand the molecular and structural chemical and biological aspects of disease-related processes as well as developing chemical tools for treatment of diseases.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Mario van der Stelt has been appointed Professor of Molecular Physiology at the Leiden Institute of Chemistry with effect from 1 November 2017.

The Leiden Observatory has appointed a new professor. Selena Viti will hold a chair in Molecular Astrophysics. Viti will build a research group that combines different research techniques to unravel the secrets of local and external galaxies. ‘My main ambition is to change the way scientists interpret…

Chemists developed a new graphene-transferring method which makes use of cyclohexane. This new method leaves less impurities on graphene, is easier to handle than current methods and is widely applicable in graphene research. The publication will be on the cover of the journal ACS Central Science late…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…

Leiden University organizes a course on quantum mechanics for high school Physics teachers. As the curriculum gains a new quantum component, the university enables teachers to give the best possible guidance to their students.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Promotor: Prof.dr. H.L.V. Linnartz

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. The University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP) work…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotor: Prof.dr. E.F. Smets

Promotor: Prof.dr. E. Smets, Dr. M. Stech

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

How does the photoregulation mechanism work in detail?

The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…

The Leiden Institute of Chemistry offers a unique tailor-made programme in Life Science and Technology. You can adept the programme to your own interests and ambitions with the help of your own personal mentor. Your study will focus on either a Biomedical and Molecular approach of Life Sciences.

The fundamental and applied research in Leiden is focussed on either a Biomedical or Molecular approach of Life Sciences. During the Master you will be part of one of our multidisciplinary research teams.