Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

We aim to develop A. niger strains that produce more starch degrading enzymes even in the absence of starch.

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

Thread-like bacteria make cells that no longer have a cell wall under the influence of osmotic stress. A remarkable discovery, since the cell wall serves as a protection barrier for bacteria. It could also help to explain how pathogenic bacteria can hide in our body from our immune system. A team of…

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells (CTLs) is crucial. In this study, a synthetic long peptide (SLP) harbouring the model CTL epitope SIINFEKL was encapsulated…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…

A new mathematical model may explain how body cells get their shapes and what makes them move within a tissue. The model provides fundamental knowledge for applications in tissue engineering, amongst other things. Publication in open-access journal iScience.

Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The life of a fibroblast is heavy, but PhD student Julia Eckert makes it 19.5 times heavier, using the Large Diameter Centrifuge at the ESTEC space research centre in Noordwijk.

Biophysicist Rolf Harkes has developed a microscope to optically localize individual molecules in living cells. It improves monitoring of diseases like cancer and Parkinson’s at the cellular level. Defende PhD thesis on t13 January 2016.

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…

When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.

Leiden physicists are helping Wageningen plant researchers to study unpredictable plant embryos. For this, they are using a novel two-photon fluorescence microscope, aided by a 30 thousand euro ZonMW grant.

An international group of scientists has discovered that certain cells of our immune system – the so-called T cells – communicate with each other and work together as a team. To fight an infection they stimulate each other’s growth, but at the same time, they inhibit each other when there is a surplus…

With the necessary measures, researchers restart their work in various laboratories. The Leiden Cell Observatory is one of the places where scientists resume their lab work.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: T. Schmidt

Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…

Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.

Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…

Joost Beltman (LACDR, Leiden University) has provided novel insights in the way T cells migrate towards virus-infected cells. This was accomplished by a combination of experimental research in the group of Ton Schumacher (Dutch Cancer Institute, NKI) and computer simulations in collaboration with Rob…

Leiden biophysicists have found a new possible way to attack cancer cells. They have located ‘sinkholes’ on the cells where receptor proteins disappear from the surface. If a drug could push these proteins towards those areas, it would kill the cancer cell.

American pharmaceutical company Bristol Myers Squibb will be building a new (CAR-T) cell therapy facility in the Oegstgeest part of the Leiden Bio Science Park. The company will manufacture and develop CAR T-cell therapy for patients with blood cancer (leukaemia), for example.

Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.

Geneticist Hans Clevers will give the first Niko Tinbergen lecture new style on 10 December, which is all about stem cells. The young Leiden professors Ariane Briegel and Susana Chuva de Sousa Lopes talk about bacterial noses and the cultivation of egg cells in the lab in short introductory lectures…

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Theoretical physicist Luca Giomi receives a 2 million euro ERC Consolidator Grant for research into flowing cells in a strange hexatic phase, which is half fluid, half solid.

The Netherlands Council of State ruled at the end of March that WhatsApp and text messages on the work and private cell phones of civil servants are considered to be official records. This decision puts the government in a difficult position. How are you going to store millions of texts and WhatsApp…

The Leiden University Medical Center (LUMC) will start construction this year of the largest non-profit stem cell and gene therapy facility in the Netherlands, and one of the largest facilities in Europe. NECSTGEN – the Netherlands Center for the Clinical Advancement of Stem Cell and Gene Therapies…