Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

The aim of current study was to develop a dried inactivated polio vaccine (IPV) formulation with minimal loss during the drying process and improved stability when compared with the conventional liquid IPV.

The Equadiff conferences are a series of international meetings devoted to the field of differential equations in the broadest sense. Spread all over Europe, recent locations include Bratislava (2017), Lyon (2015), Prague (2013), Loughborough (2011), Brno (2009), Vienna (2007), Bratislava (2005),…

In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…

Oratie

Lezing

Lezing

Promotie

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

Can animal venoms yield novel antimicrobial peptides?

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.

List of Support Departments at LION and the Faculty of Science

Promotor: G.P. van Wezel

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Leiden University has developed a radically different method for large scale production of diverse nanoparticles and their alloys.

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

On 13 October 2021 Ross Spence defended the thesis 'Collateral Transactions and Shadow Banking'. The doctoral research was supervised by Prof. M. Haentjens and Prof. A.M. Pacces (UvA).

The focus of our theoretical research is understanding the behaviour of soft condensed matter, physical matter which is deformed or structurally altered by thermal fluctuations or small stresses.

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

What are the functions of the endocannabinoid system?

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Geometric phases lead to a nontrivial interference result when an electron's different quantum mechanical paths choices encircle a magnetic coil in an Aharonov-Bohm experiment.

Promotor: Prof.dr. G.P. van Wezel

Microscopic spheres that can self-propel through a liquid move faster over a hydrophobic surface than they do over a hydrophilic surface. ‘This was a surprise,’ says Stefania Ketzetzi, the researcher who discovered the effect. Understanding how these artificial spheres move is important for understanding…

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.

Lezing

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

On 1 July 2020, Niek Strohmaier defended his thesis 'Making Sense of Business Failure'. The doctoral research was supervised by Prof. J.A.A. Adriaanse en dr. H. Pluut.

Within the Department of Business Studies, the chair ‘Insolvency Law’ is also aimed at research in the field of restructuring and insolvency, but more from a legal perspective.

We are a dynamic research group at the Leiden Institute of Physics. Our aim is to explore and understand quantum materials, including strange metals, high-temperature superconductors, and quantum critical electron matter.

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to characterize, and to accurately predict the outcome of chemical reactions at gas-solid and liquid-solid interfaces. Here the solid surface is typically a metal or an ice surface. These goals are important to many areas in…

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

Nataliia Machushynets (IBL) and Yevhenii Radchenko (LIC) are two PhD candidates from Ukraine. They collect goods for their homecountry. Please find all the details below and support their initiative!