The present study explores the role of water in the ancient Roman city of Ostia.In antiquity, Ostia was situated at the intersection of the Tiber River and the Mediterranean Sea, and acted as one of the harbour cities of Rome for several centuries.This study investigates how water was acquired, used,…

Water, Urbanism, and Sustainability in Roman Ostia

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

111 years ago, Heike Kamerlingh Onnis liquified helium for the first time, a tour the force that netted him the Nobel prize. It took a laboratory of a size rarely seen. Now, ultracold helium has become a commodity for physics research. In Wolfgang Löffler's lab, it is ready at hand thanks to a coffee…

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

LCD screens use liquid crystals which have a high degree of order, even though they form a fluid. A new theory maps out the interplay between order, temperature and symmetry. Publication in Physical Review X.

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

Koen Bastiaans and his colleagues discovered a new quantum liquid unlike anything ever seen. They did it by using a technique that can be compared to listening to the sound of raindrops falling on a roof. Publication in Science 29 October.

After 2 years of planning, designing, testing and adjusting, the brand-new low-vibration physics lab at the new Gorlaeus Building of the Science Campus is working like a charm and ready to make its mark in the world of science. Also, the renewed facility for the production of liquid helium is all do…

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

Promotor: J. Zaanen

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The Cryogenics Department has a liquid helium production unit and an automatic liquid nitrogen filling plant.

What are the mysteries behind soft condensed matter?

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotie

Promotie

Publication in Proceedings of the National Academy of Sciences.

The research aim of the Catalysis and Surface Chemistry group headed by Prof. Marc Koper is to probe and understand chemical reactions on well-defined, mostly single crystalline, surfaces at the molecular level.

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Promotie

Lezing, Archaeological Forum

Promotie

The Biologics Formulation Group is led by Prof. Wim Jiskoot. A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals…

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Promotor: M.A.G.J. Orrit

Promotor: Prof.dr. M.L. van Hecke

While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The potential of bioneedles to deliver influenza vaccines was investigated.

Formulation of biopharmaceuticals

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

To better prepare students for lab sessions, a team from the BSc-programme Bio-Pharmaceutical Sciences (BFW) creates interactive videos. These videos use humour and examples to show students basic skills and commonly used procedures. 'We want to make education more efficient and fun.'

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra