The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

What are the functions of the endocannabinoid system?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Here are some systems and infrastructures that are useful to students.

Here are some systems and infrastructures that are useful to students.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Complex systems can be characterized as systems in which multiple components interact with each other, often in non-linear ways. The main goal of this research will be to investigate if and how the international tax system can be defined and modelled as a complex system. Approaching the international…

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Every year, Leiden University welcomes some 27,000 students from 115 different countries. In educating these students, we are committed to ensuring that the quality of our tuition meets or exceeds the highest-possible standards.

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Mathematical models of software systems enable characterizations, abstractions, simulations, and analysis of complex software during its development.

The correctness of computational systems is of great importance to our society, since it becomes ever more reliant on the benefits of computing.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

The research of our group is centered around dynamical systems, functional analysis and their interplay.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

The two-years master’s specialisation System Biomedicine and Pharmacology at Leiden university focuses on predicting drug response with computational modelling, developing individualised therapies, and developing innovative analytical tools for personalised health strategies.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

How do balanced lethal systems originate and persist in nature?

The ambition of the Medical Systems Biophysics and Bioengineering group led by Alireza Mashaghi is to develop and use physics and engineering concepts and tools for pathophysiology, diagnostics and therapy.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

This book explores the boundaries of the category of gender and their theoretical significance within the framework of Canonical Typology.

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

Duality, stochastic processes

We study the physics of a broad range of biological and soft materials

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Research into research improves the academic system. CWTS studies and evaluates the academic system in various ways. One way is to provide information on the productivity and impact of academics by documenting how many publications they or their universities produce and how often these publications…

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang