Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

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Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

Promotor: J. Kuiper

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The current hepatitis B vaccines need to be stored and transported under refrigerated conditions (2-8 degrees C). This dependence on a cold-chain is highly challenging in areas where hepatitis B virus infections are endemic.

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Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

For more information regarding ongoing research projects, please contact Dr. Ilze Bot.

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Researchers from the Netherlands Cancer Institute, the Leiden University Medical Center (LUMC) and Oncode have created a tracking system that can reveal how often cells have divided. This allowed them to find a yet undiscovered population of immune cells: young memory cells that behave like stem cells.…

What is the role of cell wall-deficiency in the persistence of tuberculosis?

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

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This book is about what happens when two people meet. Its main aim is to present an account of intersubjectivity.

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Morality, mathematics, geometry, geography, music, navigation, and language are traditionally viewed as uniquely human cultural achievements and abilities. The study of their development and variation is classified as part of the humanities and social sciences. These fields have been mainly studied…

Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.

Lezing

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The potential of liposomal cancer vaccines

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Cardiovascular disease is the leading cause of death worldwide.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Key publications of the Biologics Formulation group

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

There are a number of vaccines that require animal testing in their production. Thomas Michiels developed a replacement lab test that allows manufacturers to achieve the same result, without involving animals. The next step is that the test has to be validated by pharmaceutical companies and has to…

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Leiden professor of Cellular Immunology of Parasitic Infections Maria Yazdanbakhsh receives the prestigious NWO Spinoza Prize this year. This, in many ways, border-crossing scientist contributes with her research to more effective vaccines against parasitic infections and better medication for inflammatory…

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