PURPOSE: Determine the effect of minute quantities of sub-visible aggregates on the in vitro immunogenicity of clinically relevant protein therapeutics.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

Promotie

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Researchers Indu Khatri, Frank Staal and Jacques van Dongen from Leiden University Medical Center (LUMC) have published a perspective article in Frontiers in Immunology about coronavirus and its characteristic ‘spike protein.’ They predict which antibodies would provide the best protection against the…

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

The Laboratory for Human Osteoarchaeoloy examines human remains and their burial context to address questions about the human past.

Human trafficking is a very topical social problem, which because of both its social and legal complexity, can only be studied in an interdisciplinary way. Combating human trafficking currently features high on national and international policy agendas.

Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer

Despite the field’s general agreement that pyrotechnology had a significant impact on the cultural evolution of humankind, our understanding of the origins and development of fire use and its role in humankind’s cultural evolution is very limited, blurred by strong disagreements over its chronology…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Melanie Fink, Postdoctoral Researcher at the Europa Institute of Leiden University, has published her book Frontex and Human Rights, Responsibility in 'Multi-Actor Situations' under the ECHR and EU Public Liability Law. This work is based on her doctoral dissertation, which she defended in December…

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

The currently available in vitro generated human skin equivalents resemble the human skin in many aspects. However, some essential barrier characteristics do not fully mimic the native barrier. Consequently, the human skin equivalents cannot be used for screening of drugs for skin penetration.

We are very happy to welcome you to spend a semester or year studying with us in the Faculty of Humanities. Here you will find information on your course timetables and more.

Leiden’s Faculty of Humanities is one of the broadest of its kind, offering courses in no fewer than 80 different languages and a very broad spectrum of academic disciplines.

The Faculty of Humanities has 8 institutes:

The Faculty of Humanities

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

As a Faculty of Humanities graduate you are part of a valuable network. Discover how you can remain in contact with other alumni and the University!

In the Humans of Humanities series, we will do a portrait of one of our researchers, staff members or students, every other week.

On 1 October 2019 the Hazelhoff Centre for Financial law hosted its 19th guest lecture starring Paul Sharma, managing director at Alvarez & Marsal and co-head of the European Financial Industry Regulatory Advisory Services practices.

At the Faculty of Humanities, we study languages, cultures, civilisations and their connection to each other. This knowledge is relevant to society and we gladly share it with the world around us.

Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…

The Human Origins group at Leiden University studies the archaeology of hunter-gatherers, from the earliest stone tools in East Africa, more than three million years old, to the origin of sedentary societies towards the end of the last ice age.

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

Leiden University is building on its future in Leiden. As a means to achieving this aim, the University will be investing in excess of 100 million euros over the coming years in constructing the new accommodation for the Faculty of Humanities at Witte Singel and Doelensteeg. The University aims with…

At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…

This case study-based textbook in multivariate analysis for advanced students in the humanities emphasizes descriptive, exploratory analyses of various types of data sets from a wide range of sub-disciplines, promoting the use of multivariate analysis and illustrating its wide applicability. Fields…

The HARVEST project explores the dietary choices that our hominin ancestors and relatives made, by recovering information on what they consumed, and how factors like environmental variation, intrinsic biology, and development of food processing technologies could have influenced their decisions.

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Study of human cultures using computational approaches

To what extent are, can, and should, human trafficking and human smuggling be(ing) seen as interlinked phenomena? What are the consequences of seeing the phenomena as either distinct or interlinked for the way in which migrants crossing intra-Schengen borders are treated.

Leiden University is a unique international centre for the advanced study of languages, cultures, arts, and societies worldwide, in their historical contexts from prehistory to the present.

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

This volume is themed around the interdependent relationship between humans and the environment, an important topic in the work of Corrie Bakels

Studies in Human Evolution is a series of the Faculty of Archaeology, Leiden University and The Max Planck Institute for Evolutionary Anthropology, Leipzig.

Study of human cultures using computational approaches

The Faculty of Humanities consist of various academic fields. What is the common ground of all these different academics and students? They tell their story and why it matters in today’s world in 'We are Humanities'.

The master's programme in Philosophy of Humanities at Leiden University allows you to specialise in conceptual and methodological issues in the Humanities.

Are you about to move to Leiden or The Hague to study at one of Leiden University’s master programmes? It is not unusual to be a bit anxious. We want to help! The Humanities Buddy Programme has been set up to help you along the way.

What are interactive effects of human pressures on aquatic communities?

It is well-known that humans have significantly transformed ecosystems since their adoption of agriculture. However, in a deeper past, prehistoric hunter-gatherers may already have altered and modified their niche in ways that had major impacts on ecosystems.

This project focuses on the study of Neanderthal and early modern human behavior, primarily on the basis of stone tools, fauna and spatial patterns

Disciplinary History and Epistemology

For Humans of Psychology, students and staff will be put into the spotlight. At our institute prizes are won, exiting research is conducted, knowledge is harnessed, public meeting are organised and open science is highlighted. Take a look behind the scenes.