How can zebrafish research help to understand and fight human cancer?

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

Promotor: Prof.dr. R.M.H. Merks

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Can drug screening for tuberculosis treatment be made more efficient?

Promotor: J.N. Kok, Co-promotor: F.J. Verbeek

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar-Jagalska

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: Prof.dr. E. Deprettere

Which immune mechanisms are involved in host defense against Staphylococcal infection?

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

Promotie

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The facility develops and applies advanced, high-throughput methods for genomic research.

An overview of research themes and projects at ABS.

Can animal venoms yield novel antimicrobial peptides?

Promotor: Prof.dr. T. Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Promotie

Promotie

The imaging group focuses on bio-imaging, image analysis and visualization.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?

From the 11th of May Ewa Snaar-Jagalska has been appointed Professor in the field of cellular tumor biology within the Faculty of Science at the Institute of Biology Leiden. Her research focuses on the cellular tumor biology and human cancer modeling in zebrafish

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.

The LOFAR radio telescope produces petabytes of data every year. Radio Astronomers use complex multi-step pipelines to process this data and produce scientific images.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: Prof.dr. M.K. Richardson

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

How can zebrafish research help understanding human diseases?

Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…