646 zoekresultaten voor “gut immune homeostasis” in de Publieke website
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Testing of a malaria vaccine gets the green light
Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.
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Immune responses against conserved influenza epitopes: Lessons for peptide vaccination strategies
Promotie
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Regulation of DNA damage and immune response pathways by post-translational protein modification
Promotie
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Wiles and Wanderings: Immune-evasive maneuvers of skin-penetrating parasites
Promotie
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Immune modulation by schistosomes:mechanisms of regulatory B cell induction and inhibition of allergic asthma
Promotie
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High-dimensional profiling of immunotherapy responsive immune cells in cancer
Promotie
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The immune compartment at the maternal-fetal interface throughout human pregnancy
Promotie
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Exploring and Modulating the Tumor Immune Microenvironment Towards improving patient outcomes of immunotherapy in lung cancer
Promotie
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The Role of the innate and adaptive immune system in Vascular remodelling
Promotie
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Genetic manipulation and genetic-based dissection of tumor-specific immunity
Promotie
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Immune modulation by helminths and the impact on the development of type 2 diabetes
Promotie
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Respiratory tract infection: prevention, early detection and attenuation of immune response
Promotie
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resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
Promotie
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The NKG2A / HLA-E axis a novel target for immune checkpoint therapy
Promotie
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Outcome after Paediatric Stem Cell Transplantation for Inborn Errors of Immunity
Promotie
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotie
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The Anti-Citrullinated Protein Antibody immune response and its effector functions in Rheumatoid Arthritis
Promotie
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Immune regulation by CD4+CD49b+ T cells & B cell responses in arthritis
Promotie
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metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotie
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Control of Western flower thrips through jasmonate-triggered plant immunity
Promotie
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Insights from modeling metabolism and amoeboid cell motility in the immune system
Promotie
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Immune parameters affecting maternal tolerance towards the fetus in normal and aberrant pregnancies
Promotie
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Safety and efficacy after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model
Promotie
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T cell immunity against MHC-I low tumors in mouse models
Promotie
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Mast cell mediated immune modulation in experimental Rheumatoid Arthritis and atherosclerosis
Promotie
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Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
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Presentations and Lectures
Members of our research team give different types of presentations and lectures.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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The Rome Statute as Evidence of Customary International Law
On 9 April 2019, Yudan Tan defended her thesis 'The Rome Statute as Evidence of Customary International Law'. The doctoral research was supervised by Prof. dr. W.A. Schabas.
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Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager
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The serosa: an evolutionary novelty in insect eggs
What is the function of the insect serosa?
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Mathematical Institute
The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Advanced in vitro models for studying drug induced toxicity
Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price
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In vitro and in vivo evaluation of synergistic and opposing effects of Chinese herbal medicine and natural compounds on immuno-modulation.
Can we link multiple components from herbal extracts with their biological activities?
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Antibiotic combination therapies against drug resistant Gram negative pathogens
Can effective synergists be identified to enhance the effect of antibiotics against Gram negative pathogens?
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Civil Liability for Damage caused by Global Navigation Satellite System
On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Host-Microbe Interactions
Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.