567 zoekresultaten voor “genome scale metabolic reconstruction” in de Publieke website
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Terpenoids and terpenoid indole alkaloids in Catharanthus roseus cell suspension cultures
Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte
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Discrete tomography for integer-valued functions
Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg
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Error bounds for discrete tomography
Promotores: K.J. Batenburg, B. Koren
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Promotie
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LION Zomerschool: Modern Physics at all Scales
Het Leidse natuurkunde-instituut organiseert van 16 tot 26 juli haar jaarlijkse summer school ‘Modern Physics at all Scales’.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Robert Verpoorte
Wiskunde en Natuurwetenschappen
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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PhD candidate for tracer-based metabolomics to study Gaucher disease
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Aspects of Record Linkage
Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft
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Galaxy alignments from multiple angles
Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Jie Hu
Wiskunde en Natuurwetenschappen
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Microbial communities in Pampa soils; impact of land use changes, soil type and climatic conditions
Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Joost Visser benoemd tot hoogleraar Large Scale Software en Data Science
Op 15 November begon Joost Visser als hoogleraar Large Scale Software en Data Science bij het Leiden Institute of Advanced Computer Science (LIACS). Hij zal bij LIACS het software engineering onderzoek leiden en hoofd worden van het master programma ICT in Business and the Public Sector.
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Spectroscopy of two-field inflation
This thesis is about cosmological inflation and its relation to observations.
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Real-time tomographic reconstruction
Promotie
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Prior information and variational Bayes in high dimensional statistical network inference
This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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Lingxing Xu
Wiskunde en Natuurwetenschappen
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Shepherding precision gene editing with CRISPR-Cas9 variants and adenoviral vectors
Promotie
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Merging galaxy clusters: probing magnetism and particle acceleration over cosmic time
In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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CRISPR Cas-induced targeted mutagenesis with Agrobacterium mediated protein delivery
The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.
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Left Ventricular Reconstruction in Ischemic Cardiomyopathy
Promotie
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Efficient and Automatic Tomographic Reconstruction Algorithms
Promotie
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Ischemia/reperfusion injury: a metabolic meltdown
Promotie
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Multimodality Imaging in Metabolic Heart Disease
Promotie
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Metabolic regulation of differentiation and maturation
Promotie
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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Fast Acquisition and Reconstruction Techniques in MRI
Promotie
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Online cursus Introduction to Comparative Indo-European Lingistics
Indo-European is the name of the language family to which English belongs, along with many sub-families such as Germanic languages and Romance languages. In this course, you will delve into the structure and origins of these branches, the oldest languages belonging to the language family, linguistic…
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Anthony Brown
Wiskunde en Natuurwetenschappen
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Promotie
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Scales of Luminosity
Lezing, Walks and Talks
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X-raying extragalactic gas: warm-hot gas in the EAGLE simulations
I have studied the hot, diffuse gas around and between galaxies. Specifically, I have used the EAGLE numerical simulations of galaxy formation to predict the properties of this gas, and I have used those properties to predict specific observables: soft X-ray absorption and emission lines.
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Vacancy: PhD position Digital Art History (UU)
The Department of History and Art History externe link at Utrecht University is looking for a candidate for the PhD-project “The (R)evolution of Reconstruction: an analysis of digital facsimiles”. This project analyses the value of digital facsimiles for researchers, heritage institutions, and museum…
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Studies on molecular basics of metabolic syndrome in zebrafish
Promotie
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Promotie
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Role of intestinal microbiota in cardio-metabolic disease
Promotie
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Combatting metabolic disease. Ethnic aspects, mechanisms and novel treatment strategies
Promotie