2,016 zoekresultaten voor “gene expression” in de Publieke website
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Research Technician – tumor cell biology
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
- Research Dossiers
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Felix Wittleben
Wiskunde en Natuurwetenschappen
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Tom van der Wel
Wiskunde en Natuurwetenschappen
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Chao Du
Wiskunde en Natuurwetenschappen
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Pingtao Ding
Wiskunde en Natuurwetenschappen
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Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.
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Snake genomes revealed for King Cobra and Burmese Python
Freek Vonk and Mike Richardson, with many collaborators, have published two snake genomes in two parallel articles in the prestigious journal PNAS. Their new findings provide insight into the co-evolutionary arms race between predator and prey.
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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Using fungi to produce renewable energy
Ebru Alazi ‘hacked’ an enzyme-producing system in the fungus Aspergillus niger in order to produce renewable energy more easily. She manipulated the fungus, making it produce more pectinases: enzymes mainly used in the food industry and in the production of renewable energy, such as biofuels. Promotion…
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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Statistical ‘rockstar’ Brad Efron opens Leiden statistics centre
He is said to be one of the greatest living statisticians. Bradley Efron gave a lecture in Marekerk and opened LUXs, the Leiden University Center for Statistical Science, the first university statistics centre in the Netherlands.
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Programme structure
The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.
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Evania Fasya
Faculteit der Sociale Wetenschappen
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Alan Sears
Faculteit Rechtsgeleerdheid
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Movements of steroid receptors inside the cell nucleus unraveled
Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.
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Looking back at the Lorentz Workshop
“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”
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16S rRNA Gene Profiling
Promotie
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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The impact of anti-terrorism legislation on the freedom of expression in France and Turkey
The Europa Institute has invited Dorjana Bojanovska from Macedonia to visit Leiden Law School to conduct her master thesis research from 6 March - 31 March 2017. Dorjana is a student at the Comparative Constitutional Law program at the Legal Studies Department of the Central European University. The…
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Candidates draft report For the UN Special Rapporteur on Freedom of Expression
Prof. Mark Leiser and a team of thirteen law students from Leiden University’s Advanced LLM programmes in European and International Human Rights Law as well as in Law and Digital Technologies together drafted a report for the UN Special Rapporteur on the Promotion and Protection of the Right to Freedom…
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Heat-killed Staphylococcus aureus reduces atherosclerosis by inducing anti-inflammatory macrophages
Publication by: Vanessa Frodermann, Janine van Duijn, Gijs van Puijvelde, Peter van Santbrink, Max Lagraauw, Margreet de Vries, Paul Quax, Ilze Bot, Amanda Foks, Saskia de Jager and Johan Kuiper. Journal of Internal Medicine. 2016;279:592-605.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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"Normal" Feelings in "Abnormal" Worlds, On the Political Uses of Emotion in Science Fiction Manga
Carl Li defended his thesis on 30 June 2015
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Leiden scientists map cell types in fetal kidney
Kidney failure is a serious issue because kidneys cannot regenerate themselves after injury. A possible solution consists of artificially growing healthy kidney tissue. To achieve that, scientists first need to understand kidney development during the earliest stages, in the fetus. Leiden researchers…
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alumnus Clarence Charles on functions of calypso music as a cultural expression
Charles wrote an article 'Assimilating Afro Caribbean Carnivalesque Culture' for the publication 'Understanding América. The essential contribution of Afro-American music to the sociocultural meaning of the continent'
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Gene regulation in embryonic development
Promotie
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Tarlach McGonagle
Faculteit Rechtsgeleerdheid
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Guilherme Peixoto Migliora
Faculteit Rechtsgeleerdheid
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Eva Nave
Faculteit Rechtsgeleerdheid
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Matching medication to DNA leads to 30% fewer side effects
According to the LUMC, patients experience 30% fewer serious side effects when medication doses are tailored to their DNA.
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Our genome captured in numbers
‘It's where disciplines intersect that the most exciting scientific questions arise.' This was the message given by John van Noort, Professor of Biophysics, in his inaugural lecture. His own research is at the interface between biology and physics. Inaugural lecture 23 April.
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Proteins and DNA loops: Science-Groot grant for Remus Dame
How do our cells keep DNA stored away? To find out, biochemist Remus Dame received a 3 million euro Science-Groot grant. Leiden University will share the grant with TU Delft, VU Amsterdam and the Hubrecht Institute.
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ADAPTED
The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.