Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Does an Emotional Working Memory Training show a beneficial transfer effect on emotion regulation (reappraisal) capacities in patients with Borderline Personality Disorder?

Simulation is a formal scientific method used to develop, compare and test hypotheses (models). In the last few decades the use of simulation has increased dramatically in virtually all scientific disciplines, but is still limited in archaeology due to the technological barrier – coding skills. Starting…

Valérie Pattyn, Assistant Professor at Leiden University, researched

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Electrical signals travel like a wave through our neural pathways. The mathematical models for these movements could not yet properly describe all the biological properties of the nerves. PhD student Willem Schouten-Straatman changed this by improving the existing models. ‘I hope that one day we will…

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

Wiskunde en Natuurwetenschappen

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Three types of PLCs are studied, varying on the dimension of autonomy of and interdependency between teachers: Joint work, Aid and assistance and Shared practices.

Source: Mediators Inflamm (2014)

The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.

Demonstration experiments are a potentially powerful instrument to improve the micro-macro thinking of students in secondary education. Therefore we want to design a practical and generative approach to assist teachers to develop lessons with a demonstration experiment.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

Experts from several disciplines have raised concerns about the use of seemingly precise models to guide policies in matters as complex as the current Covid-19 pandemic. 22 scholars wrote down five principles on how to responsibly use scientific models. This comment was published in Nature on 24 June…

Can epigenetic changes explain associations between early life stress and health outcomes?

What is the optimal way to utilise intermediate assessment in improving study behaviour and study success?

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.

When new features are being written into software code, errors can easily be made. This causes bugs, which leads to software appearing later and being more expensive. Michiel Helvensteijn, a PhD student from CWI and the Leiden Institute of Advanced Computer Science, studied how to prevent these kinds…

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Matthijs van Leeuwen of the Leiden Institute of Advanced Computer Science develops methods to make computer models interactive. With interactive models, experts can combine information from raw data with their own knowledge to make predictions more accurate. 'In this way we hope to build models that…

Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…

On 20 October 2021 Michael Ramsden defended the thesis 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. The doctoral research was supervised by Prof. N.M. Blokker.

In February 2014, the Swiss voting population accepted a constitutional initiative that aims at limiting migration through quota and, in the field of employment, national preference.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

Is the legitimacy of law and governance of multilevel jurisdictions diminishing?” “What is the significance of (diminishing) legitimacy for the effectiveness of law?” These kinds of questions about the legitimacy of the supranational formation of law, its application, and the policy and governance based…

Mechanical interactions between cells and their environment play an important role in many biological processes.

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…

The global population speaks approximately 7,000 different languages and approximately half of the world’s population is bilingual. The unique orthographic characteristics of different languages can help us to gain insight into the seemingly simple process of transforming written to spoken words (i.e.,…

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

The overall aim of the project is to investigate effective ways to strengthen vocational identity of at-risk adolescents in order to contribute to a successful transition from late secondary to post secondary lower vocational education or to work.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

Assistant Professor Vedran Dunjko and his team received a gift from Google to support their quantum research. The research focuses on whether quantum computers can provide new ways of understanding the mysteries of high-energy physics.