Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Wiskunde en Natuurwetenschappen, Centrum voor Milieuwetenschappen Leiden (CML)

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

Unfolding potential

In the thesis the dynamics of strategies is studied from two perspectives.In the first part of the thesis strategies are considered to be opinions present in a community.

In this thesis, dynamic testing principles were applied to examine young children's potential for learning. Our studies focused on the role of cognitive flexibility, to further increase our understanding of the cognitive processes involved in children's ability to learn from instruction and feedback,…

Promotor: Prof.dr. B.R. Katzy, Co-promotor: R. Ortt

An assessment approach that tailors to children’s instructional needs

Promotor: Prof.dr. W.Th.F. den Hollander, Co-promotor: R. Fernandez

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Roeland M.H. Merks

Promotor: Prof.dr. S.F. Portegies Zwart, Co-promotor: D.C. Heggie

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

The research of our group is centered around dynamical systems, functional analysis and their interplay.

If gifted children are experts in using strategies, why do they experience problems with learning? Why do they underachieve?

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Actin Polymerization and Membrane Physics in Living Cells: Analysis of cell spreading mechanisms

Promotor: W.Th.F. den Hollander

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

The book 'The United Nations Convention on the Rights of the Child' is the result of the international academic conference – ’25 Years CRC’ – which was held in November 2014 in Leiden on the occasion of the 25th birthday of the UN Convention on the Rights of the Child.

Promotor: J.W. van Holten

What is the relationship between outcomes of dynamic testing and cognitive flexibility in young children?

Promotor: Huub de Groot, Co-promotor: Francesco Buda

John van Noort

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Does a moving hybrid zone leave a genomic footprint?

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Cell adhesion signaling

Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

This computational approach to the complexity of text comprehension is useful for describing the cognitive processes involved.

Existing work in probabilistic language modeling can be mostly divided into two categories: (i) Purely sequential, string-level approaches ensure fluency at the local level without notion of grammaticality and seek improvements in the use of massive training corpora. (ii) Fully structural, tree-based…

In the early universe, the dynamics of the Higgs field can give rise to many interesting phenomena.

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.